Difference between revisions of "Klinefelter syndrome"

From Libre Pathology
Jump to navigation Jump to search
Line 2: Line 2:


==Prevalence==
==Prevalence==
*1 in 500.<ref name=pmid20348547>{{Cite journal  | last1 = Vignozzi | first1 = L. | last2 = Corona | first2 = G. | last3 = Forti | first3 = G. | last4 = Jannini | first4 = EA. | last5 = Maggi | first5 = M. | title = Clinical and therapeutic aspects of Klinefelter's syndrome: sexual function. | journal = Mol Hum Reprod | volume = 16 | issue = 6 | pages = 418-24 | month = Jun | year = 2010 | doi = 10.1093/molehr/gaq022 | PMID = 20348547 }}</ref>
*1 in 500 males.<ref name=pmid20348547>{{Cite journal  | last1 = Vignozzi | first1 = L. | last2 = Corona | first2 = G. | last3 = Forti | first3 = G. | last4 = Jannini | first4 = EA. | last5 = Maggi | first5 = M. | title = Clinical and therapeutic aspects of Klinefelter's syndrome: sexual function. | journal = Mol Hum Reprod | volume = 16 | issue = 6 | pages = 418-24 | month = Jun | year = 2010 | doi = 10.1093/molehr/gaq022 | PMID = 20348547 }}</ref>


==Characteristics==
==Characteristics==

Revision as of 04:31, 27 March 2012

Klinefelter syndrome, abbreviated KS, is a common genetic abnormality in men.

Prevalence

  • 1 in 500 males.[1]

Characteristics

Mnemonic Mr KLINE FELT Some Guys:[2]

  • Male phenotype.
  • Karyotype usu. 47,XXY
  • Long/tall.
  • Infertile.
  • Nondisjunction of sex chromosomes.
  • Eunuchoid body proportions.
  • FSH elevated, minimal Facial & axillary hair.
  • Estradiol/testosterone ratio elevation.
  • LH elevated, Leukemias risk increase (AML), Learning disability.
  • Testosterone low.
  • Small penis & testis.
  • Gynecomastia.

See also

References

  1. Vignozzi, L.; Corona, G.; Forti, G.; Jannini, EA.; Maggi, M. (Jun 2010). "Clinical and therapeutic aspects of Klinefelter's syndrome: sexual function.". Mol Hum Reprod 16 (6): 418-24. doi:10.1093/molehr/gaq022. PMID 20348547.
  2. URL: http://www.lifehugger.com/moc/2840/Klinefelters_syndrome_KS. Accessed on: 27 March 2012.