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Difference between revisions of "Kidney tumours"
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→Hereditary renal cell carcinoma: more
(→Subtypes of RCC: more) |
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Notes:<br> | Notes:<br> | ||
*A total of ten hereditary renal cancer syndromes have been described. In eight of the ten the gene is known.<ref name=pmid20817385>{{Cite journal | last1 = Verine | first1 = J. | last2 = Pluvinage | first2 = A. | last3 = Bousquet | first3 = G. | last4 = Lehmann-Che | first4 = J. | last5 = de Bazelaire | first5 = C. | last6 = Soufir | first6 = N. | last7 = Mongiat-Artus | first7 = P. | title = Hereditary renal cancer syndromes: an update of a systematic review. | journal = Eur Urol | volume = 58 | issue = 5 | pages = 701-10 | month = Nov | year = 2010 | doi = 10.1016/j.eururo.2010.08.031 | PMID = 20817385 }}</ref> | *A total of ten hereditary renal cancer syndromes have been described. In eight of the ten the gene is known.<ref name=pmid20817385>{{Cite journal | last1 = Verine | first1 = J. | last2 = Pluvinage | first2 = A. | last3 = Bousquet | first3 = G. | last4 = Lehmann-Che | first4 = J. | last5 = de Bazelaire | first5 = C. | last6 = Soufir | first6 = N. | last7 = Mongiat-Artus | first7 = P. | title = Hereditary renal cancer syndromes: an update of a systematic review. | journal = Eur Urol | volume = 58 | issue = 5 | pages = 701-10 | month = Nov | year = 2010 | doi = 10.1016/j.eururo.2010.08.031 | PMID = 20817385 }}</ref> | ||
===Molecular=== | |||
Recurrent molecular changes in RCC: | |||
*Clear cell RCC: | |||
**Loss of 3p - contains the VHL gene. | |||
*Papillary RCC: | |||
**Sporadic: | |||
***Trisomy 7, 16, 17. | |||
***Loss of Y. | |||
**Familial: | |||
***Trisomy 7 - contains MET gene.<ref>{{OMIM|164860}}</ref> | |||
==Grading RCC== | ==Grading RCC== | ||