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Neuropathology tumours (view source)
Revision as of 21:52, 24 February 2012
, 21:52, 24 February 2012→Metastatic tumours
(→Chordoma: rm broken links) |
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† Rosenthal fibres at the periphery of a lesion are a non-specific finding seen in chronic processes. | † Rosenthal fibres at the periphery of a lesion are a non-specific finding seen in chronic processes. | ||
==Metastatic tumours== | ==Metastatic brain tumours== | ||
===General=== | ===General=== | ||
*Most common brain tumour in adults. | *Most common brain tumour in adults. | ||
**Usually carcinomas - commonly [[lung cancer|lung]], [[invasive breast cancer|breast]], [[colorectal carcinoma|colon/rectum]]. | |||
===Microscopic=== | ===Microscopic=== | ||
Features: | Appearance varies by subtype. | ||
* | |||
Features of metastatic carcinoma: | |||
*Tubule formation/glands. | |||
*Usually well-circumscribed/sharply demarcated from surrounding tissue. | |||
*Usually nuclear atypia including: | |||
**Nuclear hyperchromasia. | |||
**Variation of nuclear size. | |||
**Variation of nuclear shape. | |||
*Mitoses - common. | |||
Images: | Images: | ||
*[http://commons.wikimedia.org/wiki/File:Metastatic_adenocarcinoma_-_cerebellum_-_very_low_mag.jpg CRC metastasis to cerebellum - very low mag. (WC)]. | *[http://commons.wikimedia.org/wiki/File:Metastatic_adenocarcinoma_-_cerebellum_-_very_low_mag.jpg CRC metastasis to cerebellum - very low mag. (WC)]. | ||
*[http://commons.wikimedia.org/wiki/File:Metastatic_adenocarcinoma_-_cerebellum_-_high_mag.jpg CRC metastasis to cerebellum - high mag. (WC)]. | *[http://commons.wikimedia.org/wiki/File:Metastatic_adenocarcinoma_-_cerebellum_-_high_mag.jpg CRC metastasis to cerebellum - high mag. (WC)]. | ||
===IHC=== | |||
Carcinomas: | |||
*Pankeratin +ve. | |||
*TTF-1 -- typically positive in [[lung adenocarcinoma]] and SCLC. | |||
Other markers for carcinoma - see [[immunohistochemistry]]: | |||
*CK7. | |||
*CK20. | |||
*ER. | |||
*PR. | |||
==Infiltrative astrocytomas== | ==Infiltrative astrocytomas== | ||