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Difference between revisions of "Hodgkin lymphoma"
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Diagnosis: | Diagnosis: | ||
*HL cannot be diagnosed with standard flow cytometry (FC) - but has been diagnosed with specialized FC.<ref>{{cite journal |author=Fromm JR, Thomas A, Wood BL |title=Flow cytometry can diagnose classical hodgkin lymphoma in lymph nodes with high sensitivity and specificity |journal=Am. J. Clin. Pathol. |volume=131 |issue=3 |pages=322–32 |year=2009 |month=March |pmid=19228638 |doi=10.1309/AJCPW3UN9DYLDSPB |url=}}</ref> | *HL cannot be diagnosed with standard flow cytometry (FC) - but has been diagnosed with specialized FC.<ref>{{cite journal |author=Fromm JR, Thomas A, Wood BL |title=Flow cytometry can diagnose classical hodgkin lymphoma in lymph nodes with high sensitivity and specificity |journal=Am. J. Clin. Pathol. |volume=131 |issue=3 |pages=322–32 |year=2009 |month=March |pmid=19228638 |doi=10.1309/AJCPW3UN9DYLDSPB |url=}}</ref> | ||
==HL subtypes== | |||
Types:<ref name=Ref_WMSP567/> | |||
*Classical HL (CHL) - ~95% of HL. | |||
*Nodular lymphocyte-predominant HL (NLPHL) - ~5% of HL. | |||
==Microscopic== | ==Microscopic== | ||
Features: | ===Microscopic=== | ||
*Reed-Sternberg cell | By definition, HL has Reed-Sternberg cells (RSCs). | ||
Features (classic HL): | |||
*Reed-Sternberg cell. | |||
**Large binucleated cell. | **Large binucleated cell. | ||
**Macronucleolus - approximately the size of a RBC (~8 micrometers). | **Macronucleolus - approximately the size of a RBC (~8 micrometers). | ||
**Well-defined cell border. | **Well-defined cell border. | ||
Images: | Images (classic HL): | ||
*[http://commons.wikimedia.org/wiki/File:Hodgkin_lymphoma_cytology_large.jpg HL mixed cellularity - cytology (WC)]. | *[http://commons.wikimedia.org/wiki/File:Hodgkin_lymphoma_cytology_large.jpg HL mixed cellularity - cytology (WC)]. | ||
*[http://commons.wikimedia.org/wiki/File:Hodgkin_lymphoma_cytology_small.jpg HL mixed cellularity - cytology (WC)]. | *[http://commons.wikimedia.org/wiki/File:Hodgkin_lymphoma_cytology_small.jpg HL mixed cellularity - cytology (WC)]. | ||
*[http://en.wikipedia.org/wiki/File:Hodgkin_lymphoma_%281%29_mixed_cellulary_type.jpg HL mixed cellularity (WC)]. | *[http://en.wikipedia.org/wiki/File:Hodgkin_lymphoma_%281%29_mixed_cellulary_type.jpg HL mixed cellularity (WC)]. | ||
Features (Nodular lymphocyte-predominant Hodgkin's lymphoma): | |||
*Cells (relatively) small (compared to classic RSCs). | |||
* | *Lobulated nucleus - '''key feature'''. | ||
* | *Small nucleoli. | ||
Image (NLPHL): | |||
*[http://webpathology.com/image.asp?case=388&n=16 Popcorn cell (webpathology.com)]. | |||
==Classical HL== | ==Classical HL== | ||
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==Nodular lymphocyte-predominant HL== | ==Nodular lymphocyte-predominant HL== | ||
*AKA ''lympho-histiocytic variant''. | *AKA ''lympho-histiocytic variant''. | ||
*Abbreviated ''NLPHL''. | |||
*Different IHC and morphologic appearance that classic HL; see ''Microscopic'' (above). | |||
* | |||
* | |||
==IHC== | ==IHC== | ||