Difference between revisions of "Hemophagocytic syndrome"
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*[http://en.wikipedia.org/wiki/File:Hemophagocytic_syndrome_-_very_high_mag.jpg Hemophagocytic syndrome - very high mag. (WC)]. | *[http://en.wikipedia.org/wiki/File:Hemophagocytic_syndrome_-_very_high_mag.jpg Hemophagocytic syndrome - very high mag. (WC)]. | ||
*[http://en.wikipedia.org/wiki/File:Haemophagocytic_lymphohistiocytosis_Bone_marrow.JPG HLH (WC)]. | *[http://en.wikipedia.org/wiki/File:Haemophagocytic_lymphohistiocytosis_Bone_marrow.JPG HLH (WC)]. | ||
*[http://path.upmc.edu/cases/case601.html Hemophagocytic syndrome - several images (upmc.edu)]. | |||
==See also== | ==See also== | ||
Revision as of 09:27, 26 January 2012
Hemophagocytic syndrome, also known as hemophagocytic lymphohistiocytosis, is a rare condition often associated with viral infections.
Clinical
Features:[1]
- Fever.
- Splenomegaly.
- Jaundice.
Involved organs:
- Lymph nodes.
- Liver.
- Spleen.
- Bone marrow.
Classification
Classified by etiology:[2]
- Primary, i.e. inherited:[3]
- Secondary:
Microscopic
Features:[1]
- Macrophages with phagocytosed:
- Erythrocytes.
- Leukocytes.
- Platelets.
Images:
- Hemophagocytic syndrome - cropped - very high mag. (WC).
- Hemophagocytic syndrome - very high mag. (WC).
- HLH (WC).
- Hemophagocytic syndrome - several images (upmc.edu).
See also
References
- ↑ 1.0 1.1 Fisman DN (2000). "Hemophagocytic syndromes and infection". Emerging Infect. Dis. 6 (6): 601–8. PMC 2640913. PMID 11076718. http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2640913/?tool=pubmed.
- ↑ Gupta S, Weitzman S (January 2010). "Primary and secondary hemophagocytic lymphohistiocytosis: clinical features, pathogenesis and therapy". Expert Rev Clin Immunol 6 (1): 137–54. PMID 20383897.
- ↑ Nagai K, Yamamoto K, Fujiwara H, et al. (2010). "Subtypes of familial hemophagocytic lymphohistiocytosis in Japan based on genetic and functional analyses of cytotoxic T lymphocytes". PLoS ONE 5 (11): e14173. doi:10.1371/journal.pone.0014173. PMC 2994802. PMID 21152410. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2994802/.
- ↑ Online 'Mendelian Inheritance in Man' (OMIM) 603552
- ↑ Online 'Mendelian Inheritance in Man' (OMIM) 603553
- ↑ Jin YK, Xie ZD, Yang S, Lu G, Shen KL (June 2010). "Epstein-Barr virus-associated hemophagocytic lymphohistiocytosis: a retrospective study of 78 pediatric cases in mainland of China". Chin. Med. J. 123 (11): 1426–30. PMID 20819601.