49,260
edits
Difference between revisions of "Cytogenetic tests"
Jump to navigation
Jump to search
m
→ISH: w
(5q del) |
m (→ISH: w) |
||
| (7 intermediate revisions by the same user not shown) | |||
| Line 4: | Line 4: | ||
Findings: | Findings: | ||
*5q deletion seen in myelodysplastic syndromes.<ref>{{Cite journal | last1 = Nimer | first1 = SD. | title = Clinical management of myelodysplastic syndromes with interstitial deletion of chromosome 5q. | journal = J Clin Oncol | volume = 24 | issue = 16 | pages = 2576-82 | month = Jun | year = 2006 | doi = 10.1200/JCO.2005.03.6715 | PMID = 16735711 }} | *5q deletion seen in [[myelodysplastic syndromes]].<ref>{{Cite journal | last1 = Nimer | first1 = SD. | title = Clinical management of myelodysplastic syndromes with interstitial deletion of chromosome 5q. | journal = J Clin Oncol | volume = 24 | issue = 16 | pages = 2576-82 | month = Jun | year = 2006 | doi = 10.1200/JCO.2005.03.6715 | PMID = 16735711 }} | ||
</ref> | </ref> | ||
*Y deletion in [[MDS]]<ref name=pmid21269692>{{Cite journal | last1 = Mallo | first1 = M. | last2 = Luño | first2 = E. | last3 = Sanzo | first3 = C. | last4 = Cervera | first4 = J. | last5 = Haase | first5 = D. | last6 = Schanz | first6 = J. | last7 = García-Manero | first7 = G. | last8 = Del Cañizo | first8 = C. | last9 = Sanz | first9 = GF. | title = Clinical impact of the clone size in MDS cases with monosomy 7 or 7q deletion, trisomy 8, 20q deletion and loss of Y chromosome. | journal = Leuk Res | volume = | issue = | pages = | month = Jan | year = 2011 | doi = 10.1016/j.leukres.2011.01.003 | PMID = 21269692 }} | |||
</ref> - relatively common in old men. | |||
==ISH== | ==ISH== | ||
| Line 15: | Line 17: | ||
|- | |- | ||
| BCR/ABL1 | | BCR/ABL1 | ||
| CML or ALL | | [[CML]] or ALL | ||
| Tx | | Tx: [[imatinib]] | ||
|- | |- | ||
| MLL | | MLL<ref>{{OMIM|159555}}</ref> | ||
| ALL or AML | | ALL or AML | ||
| | | rearrangment --> marker of poor prognosis<ref>{{Cite journal | last1 = Liedtke | first1 = M. | last2 = Cleary | first2 = ML. | title = Therapeutic targeting of MLL. | journal = Blood | volume = 113 | issue = 24 | pages = 6061-8 | month = Jun | year = 2009 | doi = 10.1182/blood-2008-12-197061 | PMID = 19289854 }} | ||
</ref> | |||
|- | |- | ||
| MYC | | MYC | ||
| Line 40: | Line 43: | ||
| BCL2 | | BCL2 | ||
| [[follicular lymphoma]] | | [[follicular lymphoma]] | ||
| | | t(14;18)(q32;q21)<ref name=pmid21192062>{{Cite journal | last1 = Yanai | first1 = S. | last2 = Nakamura | first2 = S. | last3 = Takeshita | first3 = M. | last4 = Fujita | first4 = K. | last5 = Hirahashi | first5 = M. | last6 = Kawasaki | first6 = K. | last7 = Kurahara | first7 = K. | last8 = Sakai | first8 = Y. | last9 = Matsumoto | first9 = T. | title = Translocation t(14;18)/IGH-BCL2 in gastrointestinal follicular lymphoma: correlation with clinicopathologic features in 48 patients. | journal = Cancer | volume = | issue = | pages = | month = Dec | year = 2010 | doi = 10.1002/cncr.25811 | PMID = 21192062 }}</ref> | ||
|- | |- | ||
| ERBB2 (HER2) | | ERBB2 (HER2) | ||
| [[breast cancer]] | | [[breast cancer]] | ||
| prognostic, Tx (trastuzumab) | | prognostic, Tx ([[trastuzumab]]) | ||
|- | |- | ||
| EWSR1 | | EWSR1 | ||