Difference between revisions of "Intranodal palisaded myofibroblastoma"

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**[http://www.ncbi.nlm.nih.gov/pmc/articles/PMC496726/figure/F4/ Amianthoid fibers (nih.gov)].<ref name=pmid1918406>{{Cite journal  | last1 = Bigotti | first1 = G. | last2 = Coli | first2 = A. | last3 = Mottolese | first3 = M. | last4 = Di Filippo | first4 = F. | title = Selective location of palisaded myofibroblastoma with amianthoid fibres. | journal = J Clin Pathol | volume = 44 | issue = 9 | pages = 761-4 | month = Sep | year = 1991 | doi =  | PMID = 1918406 }}</ref>
**[http://www.ncbi.nlm.nih.gov/pmc/articles/PMC496726/figure/F4/ Amianthoid fibers (nih.gov)].<ref name=pmid1918406>{{Cite journal  | last1 = Bigotti | first1 = G. | last2 = Coli | first2 = A. | last3 = Mottolese | first3 = M. | last4 = Di Filippo | first4 = F. | title = Selective location of palisaded myofibroblastoma with amianthoid fibres. | journal = J Clin Pathol | volume = 44 | issue = 9 | pages = 761-4 | month = Sep | year = 1991 | doi =  | PMID = 1918406 }}</ref>
**[http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3146916/figure/F4/ Amianthoid fibers (nih.gov)].<ref name=pmid21718465/>
**[http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3146916/figure/F4/ Amianthoid fibers (nih.gov)].<ref name=pmid21718465/>
**[http://path.upmc.edu/cases/case121/micro.html IPM - several images (upmc.edu)].
*[[WC]]:
*[[WC]]:
**[http://commons.wikimedia.org/wiki/File:Intranodal_palisaded_myofibroblastoma_-_intermed_mag.jpg IPM - intermed. mag. (WC)].
**[http://commons.wikimedia.org/wiki/File:Intranodal_palisaded_myofibroblastoma_-_intermed_mag.jpg IPM - intermed. mag. (WC)].

Revision as of 06:11, 3 January 2012

Intranodal palisaded myofibroblastoma, abbreviated IPM, is a rare tumour that classically presents as an inguinal mass.[1]

General

  • Rare ~ 55 cases in the world literature.[2]

Demographics:

  • Male:female = 2:1.
  • Adults - middle age.

Location:

  • Usually inguinal lymph node.
  • Reported in retroperitoneum.[2]

Treatment:

  • Simple excision; rare recurrences have been reported.[3]

Microscopic

Features:

  1. Rim of peripheral lymphoid tissue.
  2. Spindle cells with nuclear palisading - key feature.
  3. RBC extravasation/hemorrhage.
  4. Amianthoid fibers - blood vessel surrounded by collagen with (fine) peripheral spokes.[4]
  5. Intracellular and extracellular fuchsinophilic bodies.
    • Smooth muscle actin +ve.

DDx:

Notes:

Images:

IHC

  • SMA +ve.
  • Cyclin D1 +ve.

Other:

  • S100 -ve
  • GFAP -ve.
  • CD34 -ve.
  • Desmin -ve
  • Ki-67 - low.

See also

References

  1. Nguyen, T.; Eltorky, MA. (Feb 2007). "Intranodal palisaded myofibroblastoma.". Arch Pathol Lab Med 131 (2): 306-10. doi:10.1043/1543-2165(2007)131[306:IPM]2.0.CO;2. PMID 17284119.
  2. 2.0 2.1 2.2 Sagar, J.; Vargiamidou, A.; Manikkapurath, H. (2011). "Intranodal palisaded myofibroblastoma originating from retroperitoneum: an unusual origin.". BMC Clin Pathol 11: 7. doi:10.1186/1472-6890-11-7. PMC 3146916. PMID 21718465. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3146916/.
  3. Creager, AJ.; Garwacki, CP. (May 1999). "Recurrent intranodal palisaded myofibroblastoma with metaplastic bone formation.". Arch Pathol Lab Med 123 (5): 433-6. doi:10.1043/0003-9985(1999)1230433:RIPMWM2.0.CO;2. PMID 10235504.
  4. 4.0 4.1 Bigotti, G.; Coli, A.; Mottolese, M.; Di Filippo, F. (Sep 1991). "Selective location of palisaded myofibroblastoma with amianthoid fibres.". J Clin Pathol 44 (9): 761-4. PMID 1918406.
  5. URL: http://www.merriam-webster.com/medical/fuchsinophilic. Accessed on: 3 October 2011.