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*[[AKA]] Cowden syndrome. | *[[AKA]] Cowden syndrome. | ||
===General=== | ===General=== | ||
Etiology: | |||
*PTEN gene mutation. | |||
Clinical features:<ref>{{Ref PBoD|858-9}}</ref> | Clinical features:<ref name=Ref_PBoD858-9>{{Ref PBoD|858-9}}</ref> | ||
*Hamartomatous polyps. | *Hamartomatous polyps. | ||
*Facial [[trichilemmoma]]s (hair follicle root sheath epithelium tumour). | *Facial [[trichilemmoma]]s (hair follicle root sheath epithelium tumour). | ||
*Oral papillomas. | *Oral papillomas. | ||
*Acral keratoses (peripheral keratoses). | *Acral keratoses (peripheral keratoses). | ||
Note: | |||
*Lame mnemonic ''PATH'':<ref>URL: [http://www.pathologyexpert.com/boards/onlinefiles/syndromes.htm http://www.pathologyexpert.com/boards/onlinefiles/syndromes.htm]. Accessed on: 6 December 2011.</ref> ''P''apilloma (oral), ''A''cral keratosis, ''T''richilemmoma, ''H''amartomatous polyps. | |||
===Microscopic=== | ===Microscopic=== |
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