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'''Hemangioblastoma''' is a low grade [[brain tumour]] tumour typically found the [[cerebellum]]. | |||
==General== | |||
*Usually ''cerebellar''. | |||
*Associated with [[von Hippel-Lindau syndrome]]. | |||
*WHO grade I.<ref>URL: [http://www.expertconsultbook.com/expertconsult/ob/book.do?method=display&type=bookPage&decorator=none&eid=4-u1.0-B978-1-4160-4580-9..00019-8--sc0155&isbn=978-1-4160-4580-9 http://www.expertconsultbook.com/expertconsult/ob/book.do?method=display&type=bookPage&decorator=none&eid=4-u1.0-B978-1-4160-4580-9..00019-8--sc0155&isbn=978-1-4160-4580-9]. Accessed on: 9 December 2010.</ref> | |||
==Microscopic== | |||
Features:<ref>URL: [http://emedicine.medscape.com/article/340994-media http://emedicine.medscape.com/article/340994-media]. Accessed on: 23 June 2010.</ref> | |||
*Vascular. | |||
*Polygonal stromal cells with: | |||
**Hyperchromatic nuclei. | |||
**Vacuolar cytoplasm. | |||
DDx: | |||
*Metastatic [[clear cell renal cell carcinoma]]. | |||
===Images=== | |||
<gallery> | |||
Image:Cerebellar_hemangioblastoma_intermed_mag.jpg | Hemangioblastoma - intermed. mag. (WC) | |||
Image:Cerebellar_hemangioblastoma_high_mag.jpg | Hemangioblastoma - high mag. (WC) | |||
Image:Hemangioblastoma_-_nse_-_intermed_mag.jpg | Hemangioblastoma - NSE - intermed. mag. (WC) | |||
</gallery> | |||
www: | |||
*[http://path.upmc.edu/cases/case342.html Hemangioblastoma - several images (upmc.edu)]. | |||
==IHC== | |||
Features:<ref>URL: [http://www.nature.com/modpathol/journal/v18/n6/full/3800351a.html http://www.nature.com/modpathol/journal/v18/n6/full/3800351a.html]. Accessed on: 9 December 2010.</ref> | |||
*Alpha-inhibin +ve (cytoplasm). | |||
*EMA -ve. | |||
**RCC typically +ve. | |||
*NSE +ve (nucleus + cytoplasm). | |||
**RCC typically -ve. | |||
==See also== | |||
*[[Von Hippel-Lindau disease]]. | |||
*[[Neuropathology tumours]]. | |||
==References== | |||
{{Reflist|2}} | |||
[[Category:Diagnosis]] | [[Category:Diagnosis]] | ||
[[Category:Neuropathology tumours]] | |||