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=Rare diseases= | =Rare diseases= | ||
==Goodpasture syndrome== | |||
===General=== | |||
*Very rare - estimated incidence 1/1-2 million. | |||
*Renal failure and pulmonary hemorrhage.<ref>{{cite journal | author=Goodpasture EW | title=The significance of certain pulmonary lesions in relation to the etiology of influenza | journal=Am J Med Sci | year=1919 | volume=158 | pages=863–870 | doi=10.1097/00000441-191911000-00012 | issue=6}}</ref> | |||
Clinical DDx: | |||
*[[Wegener granulomatosis]]. | |||
*Azathioprine toxicity.<ref>{{Cite journal | last1 = Stetter | first1 = M. | last2 = Schmidl | first2 = M. | last3 = Krapf | first3 = R. | title = Azathioprine hypersensitivity mimicking Goodpasture's syndrome. | journal = Am J Kidney Dis | volume = 23 | issue = 6 | pages = 874-7 | month = Jun | year = 1994 | doi = | PMID = 8203372 }}</ref> | |||
Tx: | |||
*Immune suppression & plasma exchange.<ref name=pmid12597309>{{Cite journal | last1 = Shah | first1 = MK. | last2 = Hugghins | first2 = SY. | title = Characteristics and outcomes of patients with Goodpasture's syndrome. | journal = South Med J | volume = 95 | issue = 12 | pages = 1411-8 | month = Dec | year = 2002 | doi = | PMID = 12597309 }}</ref> | |||
===Microscopic=== | |||
Features: | |||
*RPGN. | |||
**Crescentic glomerulonephritis. | |||
===IF=== | |||
*Linear IgG deposits. | |||
DDx: | |||
*AGBM disease. | |||
**Goodpasture syndrome without the pulmonary hemorrhage. | |||
==Thin glomerular basement membrane disease== | ==Thin glomerular basement membrane disease== | ||
===General=== | ===General=== |
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