Difference between revisions of "Prophylactic bilateral salpingo-oophorectomy"
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'''Prophylactic bilateral salpingo-oophorectomy''' are done to prevent the development of cancer - when there is a genetic predisposition. | '''Prophylactic bilateral salpingo-oophorectomy''' are done to prevent the development of cancer - when there is a genetic predisposition. | ||
==General== | |||
*The pathology yield in ''prophylactic bilateral salpingo-oophorectomies'' is significant but modest; in series of 26 prophylatic surgeries (BRCA1 22 individuals, BRCA2 4 individuals) there were 2 in situ carcinoma and 2 atypical proliferations.<ref name=pmid14668548>{{Cite journal | last1 = Carcangiu | first1 = ML. | last2 = Radice | first2 = P. | last3 = Manoukian | first3 = S. | last4 = Spatti | first4 = G. | last5 = Gobbo | first5 = M. | last6 = Pensotti | first6 = V. | last7 = Crucianelli | first7 = R. | last8 = Pasini | first8 = B. | title = Atypical epithelial proliferation in fallopian tubes in prophylactic salpingo-oophorectomy specimens from BRCA1 and BRCA2 germline mutation carriers. | journal = Int J Gynecol Pathol | volume = 23 | issue = 1 | pages = 35-40 | month = Jan | year = 2004 | doi = 10.1097/01.pgp.0000101082.35393.84 | PMID = 14668548 }}</ref> All of the pathology was in BRCA1 carriers. | |||
==Grossing== | ==Grossing== | ||
Revision as of 15:17, 9 June 2024
Prophylactic bilateral salpingo-oophorectomy are done to prevent the development of cancer - when there is a genetic predisposition.
General
- The pathology yield in prophylactic bilateral salpingo-oophorectomies is significant but modest; in series of 26 prophylatic surgeries (BRCA1 22 individuals, BRCA2 4 individuals) there were 2 in situ carcinoma and 2 atypical proliferations.[1] All of the pathology was in BRCA1 carriers.
Grossing
Sign out
Fallopian Tubes and Ovaries, Bilateral Salpingo-Oophorectomy: - Benign ovaries and Fallopian tubes. - NEGATIVE for malignancy.
See also
References
- ↑ Carcangiu, ML.; Radice, P.; Manoukian, S.; Spatti, G.; Gobbo, M.; Pensotti, V.; Crucianelli, R.; Pasini, B. (Jan 2004). "Atypical epithelial proliferation in fallopian tubes in prophylactic salpingo-oophorectomy specimens from BRCA1 and BRCA2 germline mutation carriers.". Int J Gynecol Pathol 23 (1): 35-40. doi:10.1097/01.pgp.0000101082.35393.84. PMID 14668548.
- ↑ Fedda FA, Euscher ED, Ramalingam P, Malpica A (July 2020). "Prophylactic Risk-reducing Hysterectomies and Bilateral Salpingo-oophorectomies in Patients With Lynch Syndrome: A Clinicopathologic Study of 29 Cases and Review of the Literature". Int J Gynecol Pathol 39 (4): 313–320. doi:10.1097/PGP.0000000000000643. PMID 31851061.
- ↑ Mingels MJ, Roelofsen T, van der Laak JA, de Hullu JA, van Ham MA, Massuger LF, Bulten J, Bol M (October 2012). "Tubal epithelial lesions in salpingo-oophorectomy specimens of BRCA-mutation carriers and controls". Gynecol Oncol 127 (1): 88–93. doi:10.1016/j.ygyno.2012.06.015. PMID 22710074.