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Difference between revisions of "Choriocarcinoma"
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| LMDDx = [[mixed germ cell tumour]], [[invasive hydatidiform mole]], [[placental site trophoblastic tumour]] | | LMDDx = [[mixed germ cell tumour]], [[invasive hydatidiform mole]], [[placental site trophoblastic tumour]] | ||
| Stains = | | Stains = | ||
| IHC = beta-hCG +ve, CD10 +ve, p63 +ve, OCT3 -ve | | IHC = beta-hCG +ve, CD10 +ve, p63 +ve, OCT3 -ve, GATA3 +ve, CK7 +ve | ||
| EM = | | EM = | ||
| Molecular = | | Molecular = | ||
| Line 119: | Line 119: | ||
*MUC-4 +ve.<ref name=pmid18059230>{{Cite journal | last1 = Mao | first1 = TL. | last2 = Kurman | first2 = RJ. | last3 = Huang | first3 = CC. | last4 = Lin | first4 = MC. | last5 = Shih | first5 = IeM. | title = Immunohistochemistry of choriocarcinoma: an aid in differential diagnosis and in elucidating pathogenesis. | journal = Am J Surg Pathol | volume = 31 | issue = 11 | pages = 1726-32 | month = Nov | year = 2007 | doi = 10.1097/PAS.0b013e318058a529 | PMID = 18059230 }}</ref> | *MUC-4 +ve.<ref name=pmid18059230>{{Cite journal | last1 = Mao | first1 = TL. | last2 = Kurman | first2 = RJ. | last3 = Huang | first3 = CC. | last4 = Lin | first4 = MC. | last5 = Shih | first5 = IeM. | title = Immunohistochemistry of choriocarcinoma: an aid in differential diagnosis and in elucidating pathogenesis. | journal = Am J Surg Pathol | volume = 31 | issue = 11 | pages = 1726-32 | month = Nov | year = 2007 | doi = 10.1097/PAS.0b013e318058a529 | PMID = 18059230 }}</ref> | ||
*CD10 +ve (10 +ve of 10 cases<ref name=pmid19145204>{{Cite journal | last1 = Kalhor | first1 = N. | last2 = Ramirez | first2 = PT. | last3 = Deavers | first3 = MT. | last4 = Malpica | first4 = A. | last5 = Silva | first5 = EG. | title = Immunohistochemical studies of trophoblastic tumors. | journal = Am J Surg Pathol | volume = 33 | issue = 4 | pages = 633-8 | month = Apr | year = 2009 | doi = 10.1097/PAS.0b013e318191f2eb | PMID = 19145204 }}</ref>). | *CD10 +ve (10 +ve of 10 cases<ref name=pmid19145204>{{Cite journal | last1 = Kalhor | first1 = N. | last2 = Ramirez | first2 = PT. | last3 = Deavers | first3 = MT. | last4 = Malpica | first4 = A. | last5 = Silva | first5 = EG. | title = Immunohistochemical studies of trophoblastic tumors. | journal = Am J Surg Pathol | volume = 33 | issue = 4 | pages = 633-8 | month = Apr | year = 2009 | doi = 10.1097/PAS.0b013e318191f2eb | PMID = 19145204 }}</ref>). | ||
*[[GATA3]] +ve.<ref name=pmid26772394>{{cite journal |authors=Osman H, Cheng L, Ulbright TM, Idrees MT |title=The utility of CDX2, GATA3, and DOG1 in the diagnosis of testicular neoplasms: an immunohistochemical study of 109 cases |journal=Hum Pathol |volume=48 |issue= |pages=18–24 |date=February 2016 |pmid=26772394 |doi=10.1016/j.humpath.2015.09.028 |url=}}</ref> | |||
Notes: | Notes: | ||