View source for Gastric adenocarcinoma and proximal polyposis of the stomach

'''Gastric adenocarcinoma and proximal polyposis of the stomach''', abbreviated '''GAPPS''', is a rare [[syndrome]] characterized by [[fundic gland polyp]]s and [[gastric adenocarcinoma]].<ref name=pmid30584346>{{Cite journal  | last1 = Rudloff | first1 = U. | title = Gastric adenocarcinoma and proximal polyposis of the stomach: diagnosis and clinical perspectives. | journal = Clin Exp Gastroenterol | volume = 11 | issue =  | pages = 447-459 | month =  | year = 2018 | doi = 10.2147/CEG.S163227 | PMID = 30584346 }}</ref><ref name=pmid21813476>{{Cite journal  | last1 = Worthley | first1 = DL. | last2 = Phillips | first2 = KD. | last3 = Wayte | first3 = N. | last4 = Schrader | first4 = KA. | last5 = Healey | first5 = S. | last6 = Kaurah | first6 = P. | last7 = Shulkes | first7 = A. | last8 = Grimpen | first8 = F. | last9 = Clouston | first9 = A. | title = Gastric adenocarcinoma and proximal polyposis of the stomach (GAPPS): a new autosomal dominant syndrome. | journal = Gut | volume = 61 | issue = 5 | pages = 774-9 | month = May | year = 2012 | doi = 10.1136/gutjnl-2011-300348 | PMID = 21813476 }}</ref>

==General==
*Very rare.
*APC promotor IB mutations.<ref name=pmid30584346/>
*Autosomal dominant inheritance.<ref name=pmid30584346/>

==Criteria==
Features - all required:<ref name=pmid30584346/>
*Polyps of stomach - body and fundus only.
**>100 polyps in index case ''or'' >30 polyps in first degree relative.
**Histology predominantly [[fundic gland polyp]]s - some with dysplasia or adenocarcinoma in background.
*No colorectal or duodenal polyposis.
*Exclusion of other heritable polyposis syndrome involving the stomach, proton pump inhibitor (PPI) use.

==See also==
*[[Stomach]].
*[[Gastric adenocarcinoma]].

==References==
{{Reflist|1}}

[[Category:Diagnosis]]
[[Category:Syndromes]]
[[Category:Stomach]]