View source for Endometrium with changes due to selective progesterone receptor modulators

{{ Infobox diagnosis
| Name       = {{PAGENAME}}
| Image      = Endometrium_with_SPRM_changes_-_b_--_very_low_mag.jpg
| Width      =
| Caption    = [[Micrograph]] showing [[endometrium]] with changes due to a SPRM. [[H&E stain]].
| Synonyms   =
| Micro      = glandular changes - extensive cystic dilatation, inactive appearing glandular epithelium or abortive subnuclear vacuolization, rare mitoses or apoptotic cells, abnormal stromal vessels (common)
| Subtypes   =
| LMDDx      = [[endometrial hyperplasia]]
| Stains     =
| IHC        =
| EM         =
| Molecular  =
| IF         =
| Gross      =
| Grossing   =
| Staging    =
| Site       = [[endometrium]]
| Assdx      = [[uterine leiomyoma]]s
| Syndromes  =
| Clinicalhx = use of SPRM
| Signs      =
| Symptoms   =
| Prevalence =
| Bloodwork  =
| Rads       =
| Endoscopy  =
| Prognosis  = benign
| Other      =
| ClinDDx    =
| Tx         = (none)
}}
'''Endometrium with changes due to selective progesterone receptor modulator''' may mimic [[endometrial hyperplasia]].

'''Selective progesterone receptor modulators''', abbreviated '''SPRMs''', are a class of drugs that block the action of progesterone.  They are used to treat [[uterine fibroids]].<ref name=pmid23018219>{{Cite journal  | last1 = Williams | first1 = AR. | last2 = Bergeron | first2 = C. | last3 = Barlow | first3 = DH. | last4 = Ferenczy | first4 = A. | title = Endometrial morphology after treatment of uterine fibroids with the selective progesterone receptor modulator, ulipristal acetate. | journal = Int J Gynecol Pathol | volume = 31 | issue = 6 | pages = 556-69 | month = Nov | year = 2012 | doi = 10.1097/PGP.0b013e318251035b | PMID = 23018219 }}</ref>

==General==
*Ulipristal  - trade name ''Fibristal''.
*May be used as an emergency contraceptive.<ref name=pmid24950125>{{Cite journal  | last1 = Whitaker | first1 = LH. | last2 = Williams | first2 = AR. | last3 = Critchley | first3 = HO. | title = Selective progesterone receptor modulators. | journal = Curr Opin Obstet Gynecol | volume = 26 | issue = 4 | pages = 237-42 | month = Aug | year = 2014 | doi = 10.1097/GCO.0000000000000082 | PMID = 24950125 }}</ref>

==Microscopic==
Features:<ref name=pmid23018219/>
*Glandular changes - extensive cystic dilatation. 
*Inactive appearing glandular epithelium or abortive subnuclear vacuolization.
*Rare mitoses and apoptosis. 
*Abnormal stromal vessels - common. 

DDx:
*[[Simple endometrial hyperplasia]].

===Images===
<gallery>
Image: Endometrium with SPRM changes - a -- extremely low mag.jpg | SPRM endometrium - extremely low mag. (WC)
Image: Endometrium with SPRM changes - a -- very low mag.jpg | SPRM endometrium - very low mag. (WC)

Image: Endometrium with SPRM changes - b -- very low mag.jpg | SPRM endometrium - very low mag. (WC)
Image: Endometrium with SPRM changes - b -- low mag.jpg | SPRM endometrium - low mag. (WC)

Image: Endometrium with SPRM changes - c -- very low mag.jpg | SPRM endometrium - very low mag. (WC)
Image: Endometrium with SPRM changes - c -- low mag.jpg | SPRM endometrium - low mag. (WC)
Image: Endometrium with SPRM changes - c1 -- intermed mag.jpg | SPRM endometrium - intermed. mag. (WC)
Image: Endometrium with SPRM changes - c2 -- intermed mag.jpg | SPRM endometrium - intermed. mag. (WC)
Image: Endometrium with SPRM changes - c -- high mag.jpg | SPRM endometrium - high mag. (WC)
Image: Endometrium with SPRM changes - c1 -- very high mag.jpg | SPRM endometrium - very high mag. (WC)
Image: Endometrium with SPRM changes - c2 -- very high mag.jpg | SPRM endometrium - very high mag. (WC)
</gallery>

==See also==
*[[Uterine fibroids]].
*[[Tamoxifen]].

==References==
{{Reflist|1}}

[[Category:Drugs]]