File:Melanosis coli high mag.jpg

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Description
English: High magnification micrograph of melanosis coli (MC), also pseudomelanosis coli (PMC). Colonic biopsy. HPS stain.

Melanosis coli is a misnomer, as the pigmentation is due to lipofuscin-laden macrophages - not melanin pigment. Pseudomelanosis coli is a more appropriate descriptor, but not in common usage.

The differential diagnosis of brown pigmentation of the colon is:

  • Pseudomelanosis coli.
  • Hemosiderin-laden macrophages (old haemorrhage).
  • Melanin (rare).

PMC is predominantly seen in the cecum and right colon (ascending colon) and associated with anthracene laxative use such as senna (Senokot).

  • Low mag.
    Low mag.
  • Intermed. mag.
    Intermed. mag.
  • High mag.
    High mag.

Another case:

  • Intermed. mag.
    Intermed. mag.
  • High mag.
    High mag.
  • Very high mag.
    Very high mag.
Source Own work
Author Nephron

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current02:08, 22 October 2009Thumbnail for version as of 02:08, 22 October 20092,848 × 4,272 (3.82 MB)Nephron{{Information |Description={{en|1=High magnification micrograph of '''melanosis coli''' (MC), also '''pseudomelanosis coli''' (PMC). Colonic biopsy. H&E stain. Melan

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