View source for Lymph nodes with isolated tumour cells

'''Lymph nodes with isolated tumour cells''', also '''isolated tumour cells''' and '''isolated cancer cells''', is the presence of rare cancer cells in a lymph node.

==General==
===Definition===
*An isolated cluster of tumour cells within a lymph node in one tissue section measuring <= 0.2 mm ''or'' <200 tumour cells.<ref name=pmid19317993> {{Cite journal  | last1 = Reed | first1 = J. | last2 = Rosman | first2 = M. | last3 = Verbanac | first3 = KM. | last4 = Mannie | first4 = A. | last5 = Cheng | first5 = Z. | last6 = Tafra | first6 = L. | title = Prognostic implications of isolated tumor cells and micrometastases in sentinel nodes of patients with invasive breast cancer: 10-year analysis of patients enrolled in the prospective East Carolina University/Anne Arundel Medical Center Sentinel Node Multicenter Study. | journal = J Am Coll Surg | volume = 208 | issue = 3 | pages = 333-40 | month = Mar | year = 2009 | doi = 10.1016/j.jamcollsurg.2008.10.036 | PMID = 19317993 }}</ref><ref>{{Cite journal  | last1 = Naidoo | first1 = K. | last2 = Pinder | first2 = SE. | title = Micro- and macro-metastasis in the axillary lymph node: A review. | journal = Surgeon | volume =  | issue =  | pages =  | month = Aug | year = 2016 | doi = 10.1016/j.surge.2016.07.002 | PMID = 27498412 }}</ref>

===Significance===
*Not a significant predictor of outcome in breast pathology.<ref name=pmid24218025>{{Cite journal  | last1 = Ahmed | first1 = SS. | last2 = Thike | first2 = AA. | last3 = Iqbal | first3 = J. | last4 = Yong | first4 = WS. | last5 = Tan | first5 = B. | last6 = Madhukumar | first6 = P. | last7 = Ong | first7 = KW. | last8 = Ho | first8 = GH. | last9 = Wong | first9 = CY. | title = Sentinel lymph nodes with isolated tumour cells and micrometastases in breast cancer: clinical relevance and prognostic significance. | journal = J Clin Pathol | volume = 67 | issue = 3 | pages = 243-50 | month = Mar | year = 2014 | doi = 10.1136/jclinpath-2013-201771 | PMID = 24218025 }}</ref>

==Sign out==
<pre>
Right Breast, Modified Radical Mastectomy:
     - Two lymph nodes of six lymph nodes with ISOLATED TUMOR CELLS 
	  (<100 tumour cells per lymph node).  
	-- All lymph nodes NEGATIVE for micrometatases and 
	   NEGATIVE for macrometatases (0/4).
     - Scar and therapy changes (hyalization, calcifications) compatible 
       with treated tumour.
     - Florid epithelial hyperplasia of the usual type.
     - Please see synoptic report.

Comment:
The isolated tumour cells were demonstrated with a CAM5.2 immunostain.
</pre>

==See also==
*[[Invasive breast cancer]].
*[[Lymph node metastasis]].

==References==
{{reflist|1}}

[[Category:Lymph nodes]]