View source for Fibrosing pleuritis

'''Fibrosing pleuritis''', also '''fibrous pleurisy''' and '''fibrous pleuritis‎''', is an uncommon benign condition that mimics [[malignant mesothelioma]].

It may be referred to as ''cryptogenic bilateral fibrosing pleuritis'', if it is bilateral.

==General==
*Benign.
*No asbestos exposure.<ref name=pmid3166932>{{Cite journal  | last1 = Buchanan | first1 = DR. | last2 = Johnston | first2 = ID. | last3 = Kerr | first3 = IH. | last4 = Hetzel | first4 = MR. | last5 = Corrin | first5 = B. | last6 = Turner-Warwick | first6 = M. | title = Cryptogenic bilateral fibrosing pleuritis. | journal = Br J Dis Chest | volume = 82 | issue = 2 | pages = 186-93 | month = Apr | year = 1988 | doi =  | PMID = 3166932 }}</ref>

Clinical:<ref name=pmid3166932/>
*Pleural thickening on imaging.
*[[Pleural effusion]].

==Gross==
*Pleural thickening associated with a [[pleural effusion]].

==Microscopic==
Features:{{fact}}
*Fibrosis.
**Spindle cells.
**Moderate cellularity.
*No [[necrosis]].<ref name=pmid9704618/>
*Inflammation - lymphocytes.<ref name=pmid3166932/>

DDx:<ref name=pmid15559051>{{Cite journal  | last1 = Corson | first1 = JM. | title = Pathology of mesothelioma. | journal = Thorac Surg Clin | volume = 14 | issue = 4 | pages = 447-60 | month = Nov | year = 2004 | doi = 10.1016/j.thorsurg.2004.06.007 | PMID = 15559051 }}</ref>
*[[Mesothelioma]], desmoplastic.
*[[Pleural plaques]].

==IHC==
*p53 -ve/+ve.
**More common in mesothelioma.<ref name=pmid9704618>{{Cite journal  | last1 = Mangano | first1 = WE. | last2 = Cagle | first2 = PT. | last3 = Churg | first3 = A. | last4 = Vollmer | first4 = RT. | last5 = Roggli | first5 = VL. | title = The diagnosis of desmoplastic malignant mesothelioma and its distinction from fibrous pleurisy: a histologic and immunohistochemical analysis of 31 cases including p53 immunostaining. | journal = Am J Clin Pathol | volume = 110 | issue = 2 | pages = 191-9 | month = Aug | year = 1998 | doi =  | PMID = 9704618 }}</ref>

==Sign out==
<pre>
Pleura, Left Lung, Biopsy:
- Fibrous pleuritis/pleural plaque (fibrous tissue with mild chronic inflammation 
  and calcifications).
- NEGATIVE for evidence of malignancy.
</pre>

===Micro===
The sections show dense fibrous tissue with bland appearing fibroblasts and mild chronic inflammation. Large calcifications are present. Lung parenchyma is not seen.

Nodules are not apparent. Concerning hypercellular areas are not seen. Necrosis is not present. Nuclear atypia is not identified. Mitotic activity is not readily apparent.

==See also==
*[[Medical lung diseases]].

==References==
{{Reflist|2}}

[[Category:Diagnosis]]
[[Category:Medical lung diseases]]