View source for Lhermitte-Duclos disease

'''Lhermitte-Duclos_disease''', abbreviated '''LDD''', is a rare [[neuropathology]].

It is also known as '''dysplastic cerebellar gangliocytoma'''<ref name=pmid20060133>{{Cite journal  | last1 = Yağci-Küpeli | first1 = B. | last2 = Oguz | first2 = KK. | last3 = Bilen | first3 = MA. | last4 = Yalçin | first4 = B. | last5 = Akalan | first5 = N. | last6 = Büyükpamukçu | first6 = M. | title = An unusual cause of posterior fossa mass: Lhermitte-Duclos disease. | journal = J Neurol Sci | volume = 290 | issue = 1-2 | pages = 138-41 | month = Mar | year = 2010 | doi = 10.1016/j.jns.2009.12.010 | PMID = 20060133 }}</ref> and '''dysplastic gangliocytoma of the cerebellum'''.

==General==
*Cerebellar lesion.
*May be associated with [[Cowden syndrome]].<ref name=omim158350>{{OMIM|158350}}</ref>

==Microscopic==
Features:<ref>URL: [http://path.upmc.edu/cases/case472.html http://path.upmc.edu/cases/case472.html]. Accessed on: 21 January 2012.</ref>
*The outer (molecular) layer has increased cellularity.
*Purkinje cells absent.<ref name=pmid20060133/>
*Large (polygonal) cells with round nuclei and prominent nucleoli in the inner (granular) layer - '''key feature'''.
*+/-Microcalcifications.

===Images===
<gallery>
Image:Dysplastic gangliocytoma lhermitte duclos.jpg | LDD. (WC/Jensflorian)
</gallery>
www:
*[http://path.upmc.edu/cases/case472.html LDD - several images (upmc.edu)].

==See also==
*[[Neuropathology tumours]].

==References==
{{Reflist|2}}

[[Category:Neuropathology tumours]]
[[Category:Diagnosis]]