View source for Mesonephric adenocarcinoma

'''Mesonephric adenocarcinoma''' is a rare malignant tumour of the [[uterine cervix]].
==General==
*Arises from the [[mesonephric duct remnants]].

==Microscopic==
Features:<ref name=Ref_WMSP442>{{Ref WMSP|442}}</ref>
*Nuclear atypia - '''key feature'''.
**Nuclear crowding.
*Variable architecture:
**Tubular, papillary, solid, retiform (net-like<ref>URL: [http://www.thefreedictionary.com/retiform http://www.thefreedictionary.com/retiform]. Accessed on: 25 August 2012.</ref>).

DDx:
*[[Mesonephric duct remnants]].
*[[Cervical adenocarcinoma]].
**[[Clear cell carcinoma of the uterine cervix]].
*[[Colorectal adenocarcinoma]].
*[[Endometrioid endometrial adenocarcinoma]].

==IHC==
Features:<ref name=Ref_WMSP442>{{Ref WMSP|442}}</ref>
*CK7 +ve.
*CD10 +ve.
*AMACR +ve.
*Napsin A +ve.<ref name=pmid31361605>{{cite journal |authors=Pors J, Segura S, Cheng A, Ji JX, Tessier-Cloutier B, Cochrane D, Fix DJ, Park K, Gilks B, Hoang L |title=Napsin-A and AMACR are Superior to HNF-1β in Distinguishing Between Mesonephric Carcinomas and Clear Cell Carcinomas of the Gynecologic Tract |journal=Appl Immunohistochem Mol Morphol |volume=28 |issue=8 |pages=593–601 |date=September 2020 |pmid=31361605 |pmc=6987010 |doi=10.1097/PAI.0000000000000801 |url=}}</ref>
*HNF-1beta +ve/-ve.
**Not useful for differentiation from clear cell carcinoma of the gynecologic tract.<ref name=pmid31361605/>

Others:<ref name=Ref_WMSP442>{{Ref WMSP|442}}</ref>
*[[CK20]] -ve.
*ER -ve.
*PR -ve.
*CEA -ve.

==See also==
*[[Gynecologic pathology]].

==References==
{{Reflist|1}}

[[Category:Diagnosis]]