View source for Tissue microarray

A '''tissue microarray''' (often abbreviated: TMA) is a paraffin block (recipient) with cylindrical tissue biopsies taken from individual tissue samples (donors).

The method was introduced by Kononen et al. in 1998 <ref>{{Cite journal  | last1 = Kononen | first1 = J. | last2 = Bubendorf | first2 = L. | last3 = Kallioniemi | first3 = A. | last4 = Bärlund | first4 = M. | last5 = Schraml | first5 = P. | last6 = Leighton | first6 = S. | last7 = Torhorst | first7 = J. | last8 = Mihatsch | first8 = MJ. | last9 = Sauter | first9 = G. | title = Tissue microarrays for high-throughput molecular profiling of tumor specimens. | journal = Nat Med | volume = 4 | issue = 7 | pages = 844-7 | month = Jul | year = 1998 | doi =  | PMID = 9662379 }}</ref> and is widely used in pathology especially in tumor analysis.

<gallery>
File:Tissue MicroArray Block.jpg|Tissue microarray block.
File:Tissue MicroArray Slide.jpg|Tissue microarray slide
File:Example of tissue cross-reactivity on human tissue microarray.jpeg|IHC stains on TMA
</gallery>

[[Category:Basics]]