Pulmonary neuroendocrine cell hyperplasia

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Pulmonary neuroendocrine cell hyperplasia is a proliferation of neuroendocrine cells confined by the bronchial basement membrane.

Pulmonary neuroendocrine cell hyperplasia
Diagnosis in short

LM proliferation of neuroendocrine cells confined by the basement membrane of the bronchus.
LM DDx carcinoid tumourlet, diffuse idiopathic pulmonary neuroendocrine cell hyperplasia, pulmonary meningothelial-like nodule
Site lung

Syndromes if diffuse diffuse idiopathic pulmonary neuroendocrine cell hyperplasia (DIPNECH)

Symptoms none
Prevalence very common
Prognosis benign
Treatment none required

General

Microscopic

Features:

  • Proliferation of neuroendocrine cells - superficial to the basement membrane of the bronchus.[1][2]
    • Salt and pepper chromatin.

Note:

  • They often project into the airway.

DDx:

See also

References

  1. Koo, CW.; Baliff, JP.; Torigian, DA.; Litzky, LA.; Gefter, WB.; Akers, SR. (Sep 2010). "Spectrum of pulmonary neuroendocrine cell proliferation: diffuse idiopathic pulmonary neuroendocrine cell hyperplasia, tumorlet, and carcinoids.". AJR Am J Roentgenol 195 (3): 661-8. doi:10.2214/AJR.09.3811. PMID 20729444.
  2. Davies, SJ.; Gosney, JR.; Hansell, DM.; Wells, AU.; du Bois, RM.; Burke, MM.; Sheppard, MN.; Nicholson, AG. (Mar 2007). "Diffuse idiopathic pulmonary neuroendocrine cell hyperplasia: an under-recognised spectrum of disease.". Thorax 62 (3): 248-52. doi:10.1136/thx.2006.063065. PMID 17099078.