Collagenous gastritis

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Collagenous gastritis
Diagnosis in short

LM collagen band in superficial lamina propria
LM DDx amyloidosis of the stomach, signet ring cell carcinoma
Stains trichrome stain - demonstrate collagen
Site stomach

Associated Dx celiac sprue (in adults), collagenous colitis (in adults)
Symptoms +/-dyspepsia
Prevalence extremely rare
Blood work +/-anemia

Collagenous gastritis is an extremely rare pathology of the stomach. It is seen in children and adults.

General

  • Very rare[1] ~ 30 cases reported in world literature in 2009.[2]

Clinical

children:[3]

  • Dyspepsia or anemia.
  • Chronic.

Adults:[2]

Gross

  • Discoloured depression - focal.[1] (???)

Microscopic

Features:

  • Band of eosinophilic material (collagen) expands superficial lamina propria.[1]
    • Band of collagen must be as thick as RBC diameter.

DDx:

Images

Stains

See also

References

  1. 1.0 1.1 1.2 1.3 Jin, X.; Koike, T.; Chiba, T.; Kondo, Y.; Ara, N.; Uno, K.; Asano, N.; Iijima, K. et al. (Sep 2013). "Collagenous gastritis.". Dig Endosc 25 (5): 547-9. doi:10.1111/j.1443-1661.2012.01391.x. PMID 23363075.
  2. 2.0 2.1 Brain, O.; Rajaguru, C.; Warren, B.; Booth, J.; Travis, S. (Dec 2009). "Collagenous gastritis: reports and systematic review.". Eur J Gastroenterol Hepatol 21 (12): 1419-24. doi:10.1097/MEG.0b013e32832770fa. PMID 19730387.
  3. Hijaz, NM.; Septer, SS.; Degaetano, J.; Attard, TM. (Mar 2013). "Clinical outcome of pediatric collagenous gastritis: case series and review of literature.". World J Gastroenterol 19 (9): 1478-84. doi:10.3748/wjg.v19.i9.1478. PMID 23538318.