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Difference between revisions of "Malignant melanoma"
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| IHC = S-100, Melan A, HMB-45, MITF, tyrosinase | | IHC = S-100, Melan A, HMB-45, MITF, tyrosinase | ||
| EM = melanosomes | | EM = melanosomes | ||
| Molecular = | | Molecular = +/-[[BRAF mutation]] | ||
| IF = | | IF = | ||
| Gross = | | Gross = | ||
| Line 403: | Line 403: | ||
==Molecular== | ==Molecular== | ||
* Commonly have [[BRAF mutation]]s.<ref name=pmid12460918>{{Cite journal | last1 = Brose | first1 = MS. | last2 = Volpe | first2 = P. | last3 = Feldman | first3 = M. | last4 = Kumar | first4 = M. | last5 = Rishi | first5 = I. | last6 = Gerrero | first6 = R. | last7 = Einhorn | first7 = E. | last8 = Herlyn | first8 = M. | last9 = Minna | first9 = J. | title = BRAF and RAS mutations in human lung cancer and melanoma. | journal = Cancer Res | volume = 62 | issue = 23 | pages = 6997-7000 | month = Dec | year = 2002 | doi = | PMID = 12460918 }} | |||
</ref> | |||
* Desmoplastic melanoma has the highest number of mutations (62 per megabase).<ref>{{Cite journal | last1 = Shain | first1 = AH. | last2 = Garrido | first2 = M. | last3 = Botton | first3 = T. | last4 = Talevich | first4 = E. | last5 = Yeh | first5 = I. | last6 = Sanborn | first6 = JZ. | last7 = Chung | first7 = J. | last8 = Wang | first8 = NJ. | last9 = Kakavand | first9 = H. | title = Exome sequencing of desmoplastic melanoma identifies recurrent NFKBIE promoter mutations and diverse activating mutations in the MAPK pathway. | journal = Nat Genet | volume = 47 | issue = 10 | pages = 1194-9 | month = Oct | year = 2015 | doi = 10.1038/ng.3382 | PMID = 26343386 }}</ref> | * Desmoplastic melanoma has the highest number of mutations (62 per megabase).<ref>{{Cite journal | last1 = Shain | first1 = AH. | last2 = Garrido | first2 = M. | last3 = Botton | first3 = T. | last4 = Talevich | first4 = E. | last5 = Yeh | first5 = I. | last6 = Sanborn | first6 = JZ. | last7 = Chung | first7 = J. | last8 = Wang | first8 = NJ. | last9 = Kakavand | first9 = H. | title = Exome sequencing of desmoplastic melanoma identifies recurrent NFKBIE promoter mutations and diverse activating mutations in the MAPK pathway. | journal = Nat Genet | volume = 47 | issue = 10 | pages = 1194-9 | month = Oct | year = 2015 | doi = 10.1038/ng.3382 | PMID = 26343386 }}</ref> | ||
**The high number of (C>T) transitions suggest UV radiation as main cause. | **The high number of (C>T) transitions suggest UV radiation as main cause. | ||