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Memory device - the rule of 10s:<ref name=Ref_PCPBoD8_586>{{Ref PCPBoD8|586}}</ref> | Memory device - the rule of 10s:<ref name=Ref_PCPBoD8_586>{{Ref PCPBoD8|586}}</ref> | ||
*10% extra-adrenal (e.g. carotid body, | *10% extra-adrenal (e.g. carotid body, ''Organ of Zuckerkandl'' (neighourhood of aortic bifuration/IMA branch point)). | ||
*10% bilateral. | *10% bilateral. | ||
*10% malignant. | *10% malignant. | ||
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Image:Adrenal Phaeochromocytoma 3 LP CTR.jpg|Adrenal Pheochromocytoma - low power (SKB) | Image:Adrenal Phaeochromocytoma 3 LP CTR.jpg|Adrenal Pheochromocytoma - low power (SKB) | ||
Image:Adrenal Phaeochromocytoma 3 MP CTR.jpg|Adrenal Pheochromocytoma - medium power (SKB) | Image:Adrenal Phaeochromocytoma 3 MP CTR.jpg|Adrenal Pheochromocytoma - medium power (SKB) | ||
Image:Adrenal Phaeochromocytoma 3 HP CTR.jpg|Adrenal Pheochromocytoma - high power - adrenal cortical neoplasms might be a histologic consideration with this lesion | Image:Adrenal Phaeochromocytoma 3 HP CTR.jpg|Adrenal Pheochromocytoma - high power - version with cleared cells - adrenal cortical neoplasms might be a histologic consideration with this lesion (SKB) | ||
Image:Adrenal Phaeochromocytoma 4 MP CTR.jpg|Pheochromocytoma - medium power (SKB) | Image:Adrenal Phaeochromocytoma 4 MP CTR.jpg|Pheochromocytoma - medium power (SKB) | ||
Image:Adrenal Phaeochromocytoma 4 MP2 CTR.jpg|Pheochromocytoma - medium power (SKB) | Image:Adrenal Phaeochromocytoma 4 MP2 CTR.jpg|Pheochromocytoma - medium power (SKB) | ||
Image:Adrenal Phaeochromocytoma 4 HP CTR.jpg|Adrenal Pheochromocytoma - high power (SKB) | Image:Adrenal Phaeochromocytoma 4 HP CTR.jpg|Adrenal Pheochromocytoma - high power - version with eosinophilic cytoplasm and eosinophilic globules (SKB) | ||
Image:Adrenal Phaeochromocytoma 5 LP PA.JPG|Pheochromocytoma - low power (SKB) | Image:Adrenal Phaeochromocytoma 5 LP PA.JPG|Pheochromocytoma - low power - not a great photo but shows the adrenal cortex pushes aside by the medullary pheochromocytoma (SKB) | ||
Image:Adrenal Phaeochromocytoma 5 MP PA.JPG|Pheochromocytoma - medium power (SKB) | Image:Adrenal Phaeochromocytoma 5 MP PA.JPG|Pheochromocytoma - medium power (SKB) | ||
Image:Adrenal Phaeochromocytoma MP CTR (3).jpg|Pheochromocytoma - medium power (SKB) | |||
Image:Adrenal Phaeochromocytoma MP2 CTR (2).jpg|Pheochromocytoma - medium power (SKB) | |||
Image:Adrenal Phaeochromocytoma HP CTR (2).jpg|Pheochromocytoma - high power - this grey-blue (probably a faded version of the purple blue is also fairly unique to pheochromocytoma (SKB) | |||
Image:Adrenal Phaeochromocytoma 6 MP PA.JPG|Pheochromocytoma - medium power - this pheo is composed of somewhat spindled cells (SKB) | Image:Adrenal Phaeochromocytoma 6 MP PA.JPG|Pheochromocytoma - medium power - this pheo is composed of somewhat spindled cells (SKB) | ||
Image:Adrenal Phaeochromocytoma LP CTR.jpg|Pheochromocytoma - medium power (SKB) | |||
Image:Adrenal Phaeochromocytoma MP CTR.jpg|Pheochromocytoma - medium power (SKB) | Image:Adrenal Phaeochromocytoma MP CTR.jpg|Pheochromocytoma - medium power (SKB) | ||
Image:Adrenal Phaeochromocytoma MP CTR (2).jpg|Pheochromocytoma - medium power (SKB) | Image:Adrenal Phaeochromocytoma MP CTR (2).jpg|Pheochromocytoma - medium power (SKB) | ||
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Image:Adrenal Pheochromocytoma 4 MP2 PA - Copy.JPG|Pheochromocytoma - medium power (SKB) | Image:Adrenal Pheochromocytoma 4 MP2 PA - Copy.JPG|Pheochromocytoma - medium power (SKB) | ||
Image:Adrenal Pheochromocytoma 4 HP2 PA.JPG|Pheochromocytoma - high power (SKB) | Image:Adrenal Pheochromocytoma 4 HP2 PA.JPG|Pheochromocytoma - high power (SKB) | ||
Image:Adrenal Pheochromocytoma LP RBWH.JPG|Pheochromocytoma - low power (SKB) | Image:Adrenal Pheochromocytoma LP RBWH.JPG|Pheochromocytoma - low power - shows compressed adrenal cortex to the left (SKB) | ||
Image:Adrenal Pheochromocytoma LP2 RBWH.JPG|Pheochromocytoma - low power | Image:Adrenal Pheochromocytoma LP2 RBWH.JPG|Pheochromocytoma - low power (SKB) | ||
Image:Adrenal Pheochromocytoma MP RBWH.JPG|Pheochromocytoma - medium power (SKB) | Image:Adrenal Pheochromocytoma MP RBWH.JPG|Pheochromocytoma - medium power (SKB) | ||
Image:Adrenal Pheochromocytoma HP RBWH - Copy.JPG|Pheochromocytoma - high power - another with cleared cells (SKB) | |||
Image:Adrenal Pheochromocytoma MP3 RBWH.JPG|Adrenal Pheochromocytoma - medium power (SKB) | |||
Image:Adrenal Pheochromocytoma MP4 RBWH.JPG|Pheochromocytoma - medium power (SKB) | Image:Adrenal Pheochromocytoma MP4 RBWH.JPG|Pheochromocytoma - medium power (SKB) | ||
</gallery> | </gallery> | ||
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*Sustentacular cells: | *Sustentacular cells: | ||
**S100 +ve. | **S100 +ve. | ||
Pheochromocytoma versus [[adrenal cortical carcinoma]] (ACC):<ref name=pmid20154585>{{Cite journal | last1 = Sangoi | first1 = AR. | last2 = McKenney | first2 = JK. | title = A tissue microarray-based comparative analysis of novel and traditional immunohistochemical markers in the distinction between adrenal cortical lesions and pheochromocytoma. | journal = Am J Surg Pathol | volume = 34 | issue = 3 | pages = 423-32 | month = Mar | year = 2010 | doi = 10.1097/PAS.0b013e3181cfb506 | PMID = 20154585 }}</ref> | |||
*Melan A -ve. | |||
**Positive in ACC. | |||
*Inhibin -ve. | |||
**Positive in ACC. | |||
*[[Calretinin]] -ve. | |||
**Positive in ACC. | |||
A panel: | |||
*S-100, chromogranin, calretinin, EMA, PAX8. | |||
==[[Electron microscopy]]== | ==[[Electron microscopy]]== | ||
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==Sign out== | ==Sign out== | ||
Mete ''et al.''. created a synoptic report for these cases that may be used.<ref name=pmid24476517>{{cite journal |authors=Mete O, Tischler AS, de Krijger R, McNicol AM, Eisenhofer G, Pacak K, Ezzat S, Asa SL |title=Protocol for the examination of specimens from patients with pheochromocytomas and extra-adrenal paragangliomas |journal=Arch Pathol Lab Med |volume=138 |issue=2 |pages=182–8 |date=February 2014 |pmid=24476517 |pmc=3909881 |doi=10.5858/arpa.2012-0551-OA |url=}}</ref> The ''College of American Pathologists'' does ''not'' have a [[CAP protocols|synoptic]] for these currently (September 2021).{{fact}} | |||
<pre> | |||
Right Adrenal (Mass), Adrenalectomy: | |||
- Pheochromocytoma, margin clear. | |||
Comment: | |||
The tumour stains as follows: | |||
POSITIVE: synaptophysin, chromogranin A, S-100 (sustentacular cells). | |||
NEGATIVE: EMA, inhibin. | |||
Proliferation (Ki-67): <2% of tumour cells. | |||
The immunostaining pattern is consistent with a pheochromocytoma. | |||
</pre> | |||
===Block letters=== | |||
<pre> | <pre> | ||
ADRENAL MASS, RIGHT, ADRENALECTOMY: | ADRENAL MASS, RIGHT, ADRENALECTOMY: |
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