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=Histologic features= | =Histologic features= | ||
*Auer rods - '''used to be''' diagnostic of MDS regardless of blast count. | *[[Auer rods]] - '''used to be''' diagnostic of MDS regardless of blast count. | ||
==Dyserythropoiesis== | ==Dyserythropoiesis== | ||
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===Histology=== | ===Histology=== | ||
Features:<ref name=dg21mar20011>D. Good. 21 March 2011.</ref> | Features:<ref name=dg21mar20011>D. Good. 21 March 2011.</ref> | ||
*Micromegakaryoctes with | *Micromegakaryoctes with hypolobated nuclei. | ||
*Non-lobated nuclei of any size. | *Non-lobated nuclei of any size. | ||
*Multiple widely separated nuclear lobes. | *Multiple widely separated nuclear lobes. | ||
Image: | |||
*[http://www.atlasbloodcells.es/ficha.php?codigo=410&codigo2=499&indice=410 Dysmegakaryocytopoiesis (atlasbloodcells.es)]. | |||
=IHC= | =IHC= | ||
Typical [[IHC]] in work-up of MDS: | Typical [[IHC]] in work-up of MDS: | ||
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*#Thrombocytopenia. | *#Thrombocytopenia. | ||
*Refractory anemia with ringed sideroblasts (RARS). | *Refractory anemia with ringed sideroblasts (RARS). | ||
*Refractory cytopenia with multilineage dysplasia (RCMD).<ref name=pmid8558932>{{Cite journal | last1 = Rosati | first1 = S. | last2 = Mick | first2 = R. | last3 = Xu | first3 = F. | last4 = Stonys | first4 = E. | last5 = Le Beau | first5 = MM. | last6 = Larson | first6 = R. | last7 = Vardiman | first7 = JW. | title = Refractory cytopenia with multilineage dysplasia: further characterization of an 'unclassifiable' myelodysplastic syndrome. | journal = Leukemia | volume = 10 | issue = 1 | pages = 20-6 | month = Jan | year = 1996 | doi = | PMID = 8558932 }}</ref> | |||
*Refractory anemia with excess blasts (RAEB). | *Refractory anemia with excess blasts (RAEB). | ||
**RAEB-1. | **RAEB-1. |
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