File:Clear cell sarcoma - intermed mag.jpg

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Description
English: Intermediate magnification micrograph of a clear cell sarcoma in a tendon. It is also known as melanoma of the soft parts, due to its morphologic similarity to malignant melanoma. HPS stain.

Clear cell sarcoma has a similar immunohistochemistry when compared to melanoma; however, unlike melanoma, it has a recurrent chromosomal translocation between EWSR1 and ATF1 -- t(12;22)(q13;q12).[1]

It should not be confused with clear cell sarcoma of the kidney, a pediatric kidney tumour second only in prevalence to nephroblastoma (Wilms tumour).

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References

  1. Hisaoka M, Ishida T, Kuo TT, et al. (March 2008). "Clear cell sarcoma of soft tissue: a clinicopathologic, immunohistochemical, and molecular analysis of 33 cases". Am. J. Surg. Pathol. 32 (3): 452–60. DOI:10.1097/PAS.0b013e31814b18fb. PMID 18300804.
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Author Nephron

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current01:51, 26 June 2012Thumbnail for version as of 01:51, 26 June 20122,848 × 4,272 (6.87 MB)Nephron{{Information |Description ={{en|1=Intermediate magnification micrograph of a '''clear cell sarcoma''' in a tendon. It is also known as '''melanoma of the soft parts''', due to its morphologic ...

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