File:Chronic berylliosis - Unusual inclusions in giant cells (8054315512).jpg

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Contributed by Philip Kane, MD

The unusual inclusions seen in these giant cells appear to be cholesterol crystals with a peripheral rim of calcification. Cholesterol crystals can apparently serve as a nidus for calcification just as calcium oxalate crystals can serve as a nidus for the formation of calcific Schaumann (conchoidal) bodies. I have never previously encountered inclusions of this type.
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Chronic berylliosis - Unusual inclusions in giant cells

Author Yale Rosen from USA

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26 September 2012

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