Difference between revisions of "Vascular malformations"

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(→‎Cherry angioma: more image links)
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*Red spot.
*Red spot.
*Polypoid.
*Polypoid.
===Gross===
*Red spot - well demarcated.
Image:
*[http://missinglink.ucsf.edu/lm/DermatologyGlossary/img/Dermatology%20Glossary/Glossary%20Clinical%20Images/CherryAngioma.jpg Cherry angioma (ucsf.edu)].<ref name=ucsf_ca>URL:: [http://missinglink.ucsf.edu/lm/DermatologyGlossary/cherry_angioma.html http://missinglink.ucsf.edu/lm/DermatologyGlossary/cherry_angioma.html]. Accessed on: 13 August 2012.</ref>


===Microscopic===
===Microscopic===
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Images:
Images:
*[http://www.dermpathexpert.com/id30.html Cherry hemangioma (dermpathexpert.com)].
*[http://www.dermpathexpert.com/id30.html Cherry hemangioma (dermpathexpert.com)].
*[http://missinglink.ucsf.edu/lm/DermatologyGlossary/img/Dermatology%20Glossary/Glossary%20Histo%20Images/cherry_angioma_mid_power.jpg Cherry angioma (ucsf.edu)].<ref name=ucsf_ca>URL:: [http://missinglink.ucsf.edu/lm/DermatologyGlossary/cherry_angioma.html http://missinglink.ucsf.edu/lm/DermatologyGlossary/cherry_angioma.html]. Accessed on: 13 August 2012.</ref>


==See also==
==See also==

Revision as of 21:16, 13 August 2012

Vascular malformations come in different flavours.

Types:[1]

  1. Arteriovenous malformation.
    • Most important clinically - highest risk of bleeding.
  2. Varix.
    • One large (dilated) vein.
  3. Venous angioma.
    • Many small veins.
  4. Caverous malformation.
    • Vessels are back-to-back (no intervening parenchyma).

Also see: Sturge-Weber syndrome.

Arteriovenous malformation

General

Gross

Features:[1]

  • Classically wedge-shaped - with base toward superficial aspect and apex toward deep aspect (like pulmonary infarcts).
  • Usually middle cerebral artery distribution.

Image:

Microscopic

Features:

  • Large vessels with eccentric wall thickening.
    • "Large" = ~ 0.5 mm (0.25-1.0 mm).
      • 0.25 mm = ~ 31 RBC diameters across.

Images:

Notes:

  • There is usually one feeding artery.
  • Arteries have a well-defined internal elastic lamina and an external elastic lamina (best seen on elastic trichrome).
    • Veins do not have an external elastic lamina and have a poorly developed/thin internal elastic lamina.

Cavernous angioma

General

  • Usually diagnosed by radiology.

Microscopic

Features:

  • Vessels back-to-back/little intervening parenchyma.
    • Muscle is absent in the vessel walls - key feature.[3]

Cherry angioma

  • AKA Campbell De Morgan spots, senile angioma.

General

  • Benign.
  • Common in the elderly.

Clincal:

  • Red spot.
  • Polypoid.

Gross

  • Red spot - well demarcated.

Image:

Microscopic

Features:[5]

  • Superifical polypoid lesion that is well-circumscribed.
  • Abundant capillaries - key feature.

Images:

See also

References

  1. 1.0 1.1 Prayson RA, Kleinschmidt-DeMasters BK (November 2006). "An algorithmic approach to the brain biopsy--part II". Arch. Pathol. Lab. Med. 130 (11): 1639–48. PMID 17076525.
  2. Marchuk, DA.; Srinivasan, S.; Squire, TL.; Zawistowski, JS. (Apr 2003). "Vascular morphogenesis: tales of two syndromes.". Hum Mol Genet 12 Spec No 1: R97-112. PMID 12668602.
  3. MUN. 23 November 2010.
  4. 4.0 4.1 URL:: http://missinglink.ucsf.edu/lm/DermatologyGlossary/cherry_angioma.html. Accessed on: 13 August 2012.
  5. Busam, Klaus J. (2009). Dermatopathology: A Volume in the Foundations in Diagnostic Pathology Series (1st ed.). Saunders. pp. 546. ISBN 978-0443066542.