Urothelial dysplasia

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Urothelial dysplasia, also low-grade (urothelial) dysplasia, is a lesion of the urothelium in the ISUP/WHO 2004 classification.[1] It is precursor lesion to urothelial carcinoma that is less worrisome than urothelial carcinoma in situ.

General

The ISUP/WHO classification of flat urothelial lesions is:[1]

  • Reactive urothelial atypia.
  • Flat urothelial hyperplasia.
  • Urothelial atypia of unknown significance.
  • Urothelial dysplasia (low-grade dysplasia).
  • Urothelial carcinoma in situ (high-grade dysplasia).
  • Invasive urothelial carcinoma.

Microscopic

Features:[2]

  • Mild nuclear enlargement (~3x a resting lymphocyte) and hyperchromasia.
  • Slight disorganization of the architecture.
    • Some maturation to the surface.
  • Mitotic figures - occasional, none atypical.

DDx:

Images

See also

  1. ↑ 1.0 1.1 Hodges, KB.; Lopez-Beltran, A.; Davidson, DD.; Montironi, R.; Cheng, L. (Feb 2010). "Urothelial dysplasia and other flat lesions of the urinary bladder: clinicopathologic and molecular features.". Hum Pathol 41 (2): 155-62. doi:10.1016/j.humpath.2009.07.002. PMID 19762067.
  2. ↑ URL: http://pathology.jhu.edu/bladder/image1.cfm?case_number=10&image_number=1. Accessed on: 31 December 2013.
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