Difference between revisions of "Urothelial dysplasia"
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===Images=== | ===Images=== | ||
*[http://pathology.jhu.edu/bladder/image1.cfm?case_number=10&image_number=1 Urothelial dysplasia (jhu.edu)]. | *[http://pathology.jhu.edu/bladder/image1.cfm?case_number=10&image_number=1 Urothelial dysplasia (jhu.edu)]. | ||
==IHC== | |||
Benign/dysplasia/CIS - a comparison:<ref name=pmid12640096>{{Cite journal | last1 = Mallofré | first1 = C. | last2 = Castillo | first2 = M. | last3 = Morente | first3 = V. | last4 = Solé | first4 = M. | title = Immunohistochemical expression of CK20, p53, and Ki-67 as objective markers of urothelial dysplasia. | journal = Mod Pathol | volume = 16 | issue = 3 | pages = 187-91 | month = Mar | year = 2003 | doi = 10.1097/01.MP.0000056628.38714.5D | PMID = 12640096 }}</ref> | |||
{| class="wikitable sortable" | |||
! Diagnosis | |||
! CK20 | |||
! Ki-67 | |||
! p53 | |||
|- | |||
| Benign | |||
| +ve -- umbrella cells only | |||
| +/-basal <10% | |||
| +/-basal weak | |||
|- | |||
| Urothelial dysplasia | |||
| +ve ~30% of cases | |||
| +ve ~40% of cases | |||
| +ve ~70% of cases | |||
|- | |||
| [[Urothelial carcinoma in situ|Carcinoma in situ]] | |||
| full thickness ~70% of cases | |||
| >10% ~95% of cases | |||
| +ve ~80% of cases | |||
|} | |||
==See also== | ==See also== | ||
Revision as of 03:46, 8 January 2014
Urothelial dysplasia, also low-grade (urothelial) dysplasia, is a lesion of the urothelium in the ISUP/WHO 2004 classification.[1] It is precursor lesion to urothelial carcinoma that is less worrisome than urothelial carcinoma in situ (also known as high-grade (urothelial) dysplasia).
General
The ISUP/WHO classification of flat urothelial lesions is:[1]
- Reactive urothelial atypia.
- Flat urothelial hyperplasia.
- Urothelial atypia of unknown significance.
- Urothelial dysplasia (low-grade dysplasia).
- Urothelial carcinoma in situ (high-grade dysplasia).
- Invasive urothelial carcinoma.
Microscopic
Features:[2]
- Mild nuclear enlargement (~3x a resting lymphocyte) and hyperchromasia.
- Slight disorganization of the architecture.
- Some maturation to the surface.
- Mitotic figures - occasional, none atypical.
DDx:
Images
IHC
Benign/dysplasia/CIS - a comparison:[3]
| Diagnosis | CK20 | Ki-67 | p53 |
|---|---|---|---|
| Benign | +ve -- umbrella cells only | +/-basal <10% | +/-basal weak |
| Urothelial dysplasia | +ve ~30% of cases | +ve ~40% of cases | +ve ~70% of cases |
| Carcinoma in situ | full thickness ~70% of cases | >10% ~95% of cases | +ve ~80% of cases |
See also
References
- ↑ 1.0 1.1 Hodges, KB.; Lopez-Beltran, A.; Davidson, DD.; Montironi, R.; Cheng, L. (Feb 2010). "Urothelial dysplasia and other flat lesions of the urinary bladder: clinicopathologic and molecular features.". Hum Pathol 41 (2): 155-62. doi:10.1016/j.humpath.2009.07.002. PMID 19762067.
- ↑ URL: http://pathology.jhu.edu/bladder/image1.cfm?case_number=10&image_number=1. Accessed on: 31 December 2013.
- ↑ Mallofré, C.; Castillo, M.; Morente, V.; Solé, M. (Mar 2003). "Immunohistochemical expression of CK20, p53, and Ki-67 as objective markers of urothelial dysplasia.". Mod Pathol 16 (3): 187-91. doi:10.1097/01.MP.0000056628.38714.5D. PMID 12640096.