Transitional cell carcinoma of the ovary
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Transitional cell carcinoma of the ovary is a rare malignant ovarian tumour. It is thought to be related to high-grade serous carcinoma of the ovary.
General
- Rare.
- Traditionally in the transistional cell tumours category - in the surface epithelial group of ovarian tumours.[1]
- Thought to be related to high-grade serous carcinoma.[2]
Microscopic
Features:[3]
- Cystic spaces:
- Small - punched-out border - very common.
- Large.
- Papillae, usu. large, blunt.
- Occasionally small and filiform.
- +/-Bizarre giant cells (35%)
- +/-Gland-like tubules.
- +/-Squamous differentiation.
- +/-Psammoma bodies.
- Cells:
- Moderate basophilic cytoplasm and little intervening stroma.
- Marked nuclear pleomorphism.
- Mitoses - common.
Notes:
- Resembles urothelial carcinoma.[4]
- No Brenner tumour component (benign or malignant) should be present.[4]
Images
IHC
Features:[4]
- Vimentin +ve,
- CA-125 +ve.
- WT1 +ve.
- CK20 -ve.
- Thrombomodulin -ve.
- Uroplakin III -ve.
Notes:
- 1-6 usu. opposite pattern in urothelial cell carcinoma.
See also
References
- ↑ Humphrey, Peter A; Dehner, Louis P; Pfeifer, John D (2008). The Washington Manual of Surgical Pathology (1st ed.). Lippincott Williams & Wilkins. pp. 401. ISBN 978-0781765275.
- ↑ Ali, RH.; Seidman, JD.; Luk, M.; Kalloger, S.; Gilks, CB. (Nov 2012). "Transitional cell carcinoma of the ovary is related to high-grade serous carcinoma and is distinct from malignant brenner tumor.". Int J Gynecol Pathol 31 (6): 499-506. doi:10.1097/PGP.0b013e31824d7445. PMID 23018212.
- ↑ Eichhorn, JH.; Young, RH. (Apr 2004). "Transitional cell carcinoma of the ovary: a morphologic study of 100 cases with emphasis on differential diagnosis.". Am J Surg Pathol 28 (4): 453-63. PMID 15087664.
- ↑ 4.0 4.1 4.2 Tazi, EM.; Lalya, I.; Tazi, MF.; Ahellal, Y.; M'rabti, H.; Errihani, H. (2010). "Transitional cell carcinoma of the ovary: a rare case and review of literature.". World J Surg Oncol 8: 98. doi:10.1186/1477-7819-8-98. PMID 21073751.