Difference between revisions of "Thyroid transcription factor-1"

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[[Image:Adenocarcinoma-Acinar type TTF1 (5494540752).jpg|thumb|right|250px|TTF-1 staining in [[lung adenocarcinoma]].]]
{{ Infobox immunostain
| Name      = {{PAGENAME}}
| Image     = Lung_adenocarcinoma_-_TTF-1_-_high_mag.jpg
| Width      =
| Caption    = TTF-1 staining in [[lung adenocarcinoma]]. (WC)
| Abbrev    =
| Synonyms  =
| Similar    =
| Clones    =     
| Use        =
| Subspecial = 
| Pattern    = nuclear staining
| Positive  = [[adenocarcinoma of the lung]], [[small cell carcinoma of the lung]], thyroid, [[hepatocellular carcinoma]] (cytoplasmic staining)
| Negative  = [[squamous cell carcinoma of the lung]]
| Other      =
}}
'''Thyroid transcription factor-1''', abbreviated '''TTF-1''' is a transcription factor seen in lung and thyroid.<ref>{{Cite journal  | last1 = Ordóñez | first1 = NG. | title = Thyroid transcription factor-1 is a marker of lung and thyroid carcinomas. | journal = Adv Anat Pathol | volume = 7 | issue = 2 | pages = 123-7 | month = Mar | year = 2000 | doi =  | PMID = 10721419 }}</ref>
'''Thyroid transcription factor-1''', abbreviated '''TTF-1''' is a transcription factor seen in lung and thyroid.<ref>{{Cite journal  | last1 = Ordóñez | first1 = NG. | title = Thyroid transcription factor-1 is a marker of lung and thyroid carcinomas. | journal = Adv Anat Pathol | volume = 7 | issue = 2 | pages = 123-7 | month = Mar | year = 2000 | doi =  | PMID = 10721419 }}</ref>


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==Tumours==
==Tumours==
*[[Lung adenocarcinoma]].<ref>{{Cite journal  | last1 = Yatabe | first1 = Y. | last2 = Mitsudomi | first2 = T. | last3 = Takahashi | first3 = T. | title = TTF-1 expression in pulmonary adenocarcinomas. | journal = Am J Surg Pathol | volume = 26 | issue = 6 | pages = 767-73 | month = Jun | year = 2002 | doi =  | PMID = 12023581 }}</ref>
===Positive staining===
*[[Small cell carcinoma of the lung]].
*[[Lung adenocarcinoma]].<ref name=pmid12023581>{{Cite journal  | last1 = Yatabe | first1 = Y. | last2 = Mitsudomi | first2 = T. | last3 = Takahashi | first3 = T. | title = TTF-1 expression in pulmonary adenocarcinomas. | journal = Am J Surg Pathol | volume = 26 | issue = 6 | pages = 767-73 | month = Jun | year = 2002 | doi =  | PMID = 12023581 }}</ref>
**[[Small cell carcinoma of the lung]].
**[[Adenocarcinoma of the lung]].
*Thyroid carcinoma.
*[[Hepatocellular carcinoma]] (cytoplasmic staining).<ref name=pmid22359993>{{Cite journal  | last1 = Mishra | first1 = M. | last2 = Morgan | first2 = V. | last3 = Hamati | first3 = AK. | last4 = Al-Abbadi | first4 = M. | title = Carcinoma of unknown primary: check the liver... thanks to TTF-1. | journal = Tenn Med | volume = 105 | issue = 1 | pages = 35-6, 40 | month = Jan | year = 2012 | doi =  | PMID = 22359993 }}</ref>
* Spindle cell oncocytoma / Pituicytoma / Granular cell tumor of the pituitary. <ref name=pmid23887161> {{Cite journal  | last1 = Mete | first1 = O. | last2 = Lopes | first2 = MB. | last3 = Asa | first3 = SL. | title = Spindle cell oncocytomas and granular cell tumors of the pituitary are variants of pituicytoma. | journal = Am J Surg Pathol | volume = 37 | issue = 11 | pages = 1694-9 | month = Nov | year = 2013 | doi = 10.1097/PAS.0b013e31829723e7 | PMID = 23887161 }}</ref>
*[[Subependymal giant cell astrocytoma]] <ref name=pmid25669749>{{Cite journal  | last1 = Hewer | first1 = E. | last2 = Vajtai | first2 = I. | title = Consistent nuclear expression of thyroid transcription factor 1 in subependymal giant cell astrocytomas suggests lineage-restricted histogenesis. | journal = Clin Neuropathol | volume = 34 | issue = 3 | pages = 128-31 | month =  | year =  | doi = 10.5414/NP300818 | PMID = 25669749 }}</ref>


Note:
===Negative staining===
*TTF-1 is negative of [[squamous cell carcinoma of the lung]].
*[[Squamous cell carcinoma of the lung]].
 
===Images===
<gallery>
File:Adenocarcinoma-Acinar type TTF1 (5494540752).jpg | TTF1 in pulmonary adenocarcinoma (WC/Yale Rosen).
File:Pituicytoma TTF1.jpg | TTF1 in a [[Pituicytoma]] (WC/jensflorian).
</gallery>


==See also==
==See also==

Revision as of 08:59, 19 April 2017

Thyroid transcription factor-1
Immunostain in short

TTF-1 staining in lung adenocarcinoma. (WC)
Normal staining pattern nuclear staining
Positive adenocarcinoma of the lung, small cell carcinoma of the lung, thyroid, hepatocellular carcinoma (cytoplasmic staining)
Negative squamous cell carcinoma of the lung

Thyroid transcription factor-1, abbreviated TTF-1 is a transcription factor seen in lung and thyroid.[1]

Positive staining

  • Nuclear staining.

Normal tissues

Tumours

Positive staining

Negative staining

Images

See also

References

  1. Ordóñez, NG. (Mar 2000). "Thyroid transcription factor-1 is a marker of lung and thyroid carcinomas.". Adv Anat Pathol 7 (2): 123-7. PMID 10721419.
  2. Yatabe, Y.; Mitsudomi, T.; Takahashi, T. (Jun 2002). "TTF-1 expression in pulmonary adenocarcinomas.". Am J Surg Pathol 26 (6): 767-73. PMID 12023581.
  3. Mishra, M.; Morgan, V.; Hamati, AK.; Al-Abbadi, M. (Jan 2012). "Carcinoma of unknown primary: check the liver... thanks to TTF-1.". Tenn Med 105 (1): 35-6, 40. PMID 22359993.
  4. Mete, O.; Lopes, MB.; Asa, SL. (Nov 2013). "Spindle cell oncocytomas and granular cell tumors of the pituitary are variants of pituicytoma.". Am J Surg Pathol 37 (11): 1694-9. doi:10.1097/PAS.0b013e31829723e7. PMID 23887161.
  5. Hewer, E.; Vajtai, I.. "Consistent nuclear expression of thyroid transcription factor 1 in subependymal giant cell astrocytomas suggests lineage-restricted histogenesis.". Clin Neuropathol 34 (3): 128-31. doi:10.5414/NP300818. PMID 25669749.