Difference between revisions of "Thyroid transcription factor-1"

From Libre Pathology
Jump to navigation Jump to search
(→‎Positive staining: SEGA + Oncocytoma)
Line 31: Line 31:
*Thyroid carcinoma.
*Thyroid carcinoma.
*[[Hepatocellular carcinoma]] (cytoplasmic staining).
*[[Hepatocellular carcinoma]] (cytoplasmic staining).
* Spindle cell oncocytoma / Pituicytoma / Granular cell tumor of the pituitary. <ref name=pmid23887161> {{Cite journal  | last1 = Mete | first1 = O. | last2 = Lopes | first2 = MB. | last3 = Asa | first3 = SL. | title = Spindle cell oncocytomas and granular cell tumors of the pituitary are variants of pituicytoma. | journal = Am J Surg Pathol | volume = 37 | issue = 11 | pages = 1694-9 | month = Nov | year = 2013 | doi = 10.1097/PAS.0b013e31829723e7 | PMID = 23887161 }}</ref>
*[[Subependymal giant cell astrocytoma]] <ref name=pmid25669749>{{Cite journal  | last1 = Hewer | first1 = E. | last2 = Vajtai | first2 = I. | title = Consistent nuclear expression of thyroid transcription factor 1 in subependymal giant cell astrocytomas suggests lineage-restricted histogenesis. | journal = Clin Neuropathol | volume = 34 | issue = 3 | pages = 128-31 | month =  | year =  | doi = 10.5414/NP300818 | PMID = 25669749 }}</ref>


===Negative staining===
===Negative staining===

Revision as of 09:18, 5 October 2015

Thyroid transcription factor-1
Immunostain in short

TTF-1 staining in lung adenocarcinoma. (WC)
Normal staining pattern nuclear staining
Positive adenocarcinoma of the lung, small cell carcinoma of the lung, thyroid, hepatocellular carcinoma (cytoplasmic staining)
Negative squamous cell carcinoma of the lung

Thyroid transcription factor-1, abbreviated TTF-1 is a transcription factor seen in lung and thyroid.[1]

Positive staining

  • Nuclear staining.

Normal tissues

Tumours

Positive staining

Negative staining

See also

References

  1. Ordóñez, NG. (Mar 2000). "Thyroid transcription factor-1 is a marker of lung and thyroid carcinomas.". Adv Anat Pathol 7 (2): 123-7. PMID 10721419.
  2. Yatabe, Y.; Mitsudomi, T.; Takahashi, T. (Jun 2002). "TTF-1 expression in pulmonary adenocarcinomas.". Am J Surg Pathol 26 (6): 767-73. PMID 12023581.
  3. Mete, O.; Lopes, MB.; Asa, SL. (Nov 2013). "Spindle cell oncocytomas and granular cell tumors of the pituitary are variants of pituicytoma.". Am J Surg Pathol 37 (11): 1694-9. doi:10.1097/PAS.0b013e31829723e7. PMID 23887161.
  4. Hewer, E.; Vajtai, I.. "Consistent nuclear expression of thyroid transcription factor 1 in subependymal giant cell astrocytomas suggests lineage-restricted histogenesis.". Clin Neuropathol 34 (3): 128-31. doi:10.5414/NP300818. PMID 25669749.