Talk:Low-grade squamous intraepithelial lesion

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LSIL criteria

The London (cytology) criteria - 2 of 3:

  1. Perinuclear clearing.
  2. Membrane irregularities (5 cells in one field - FD ~ 1.1 mm).
  3. Nuclear enlargement > 2x lymphocyte.

Augmented (London) criterium includes:

  • Neoplastic transisition (sharp transisition from normal to abnormal - gradient over 2-3 cell distance).

Required if #3 not obvious:

  • Binucleation (>2 cells).

Relative exclusions:

  • Nucleoli ( >5 in one field - FD ~ 1.1 mm).

Exclusions:

  • Cytoplasm to nucleus ratio =< 2:1; HSIL or invasive SCC.
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