TRK fusions

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TRK fusions are seen in many solid tumours and have targeted drugs.



  • TRK1.
  • TRK2.
  • TRK3.


  • The TRK genes are tyrosine kinase receptors.
  • Multiple fusion partners for each gene.

Classic associations


  • Merestinib.
  • Larotrectinib.
  • Others.

See also


  1. Lei, Y.; Chiosea, SI. (Jun 2012). "Re-evaluating historic cohort of salivary acinic cell carcinoma with new diagnostic tools.". Head Neck Pathol 6 (2): 166-70. doi:10.1007/s12105-011-0312-9. PMID 22127547.
  2. Vasudev, P.; Onuma, K. (Dec 2011). "Secretory breast carcinoma: unique, triple-negative carcinoma with a favorable prognosis and characteristic molecular expression.". Arch Pathol Lab Med 135 (12): 1606-10. doi:10.5858/arpa.2010-0351-RS. PMID 22129193.