Difference between revisions of "Subependymal giant cell astrocytoma"
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==IHC== | ==IHC== | ||
Features:<ref name=pmid9595853/> | Features:<ref name=pmid9595853/><ref name=pmid8546029>{{Cite journal | last1 = Hirose | first1 = T. | last2 = Scheithauer | first2 = BW. | last3 = Lopes | first3 = MB. | last4 = Gerber | first4 = HA. | last5 = Altermatt | first5 = HJ. | last6 = Hukee | first6 = MJ. | last7 = VandenBerg | first7 = SR. | last8 = Charlesworth | first8 = JC. | title = Tuber and subependymal giant cell astrocytoma associated with tuberous sclerosis: an immunohistochemical, ultrastructural, and immunoelectron and microscopic study. | journal = Acta Neuropathol | volume = 90 | issue = 4 | pages = 387-99 | month = | year = 1995 | doi = | PMID = 8546029 }}</ref> | ||
*GFAP +ve. ( | *GFAP +ve. (50%) | ||
*Vimentin +ve. ( | *Vimentin +ve. (100%) | ||
*S100 +ve. ( | *S100 +ve. (100%) | ||
* [[TTF-1]] (7 out of 7).<ref name=pmid25669749>{{Cite journal | last1 = Hewer | first1 = E. | last2 = Vajtai | first2 = I. | title = Consistent nuclear expression of thyroid transcription factor 1 in subependymal giant cell astrocytomas suggests lineage-restricted histogenesis. | journal = Clin Neuropathol | volume = 34 | issue = 3 | pages = 128-31 | month = | year = | doi = 10.5414/NP300818 | PMID = 25669749 }}</ref> | |||
==See also== | ==See also== | ||
Revision as of 09:22, 5 October 2015
Subependymal giant cell astrocytoma, abbreviated SEGA, is a low-grade astrocytoma associated with tuberous sclerosis complex.
General
- Associated with tuberous sclerosis complex (TSC).[1]
- WHO Grade I.
Gross/radiology
- Well-demarcated.
- Often projecting into a ventricle.
SEGA. (WC/AFIP)
Microscopic
- Giant cells with nuclear atypia ("bizarre cells").
- Glassy eosinophilic cytoplasm.
- Abundant mast cells.[4]
Images
SEGA. (WC/Sbrandner)
SEGA - NF stain. (WC/Sbrandner)
SEGA - GFAP stain. (WC/Sbrandner)
www:
IHC
See also
References
- ↑ Grajkowska, W.; Kotulska, K.; Jurkiewicz, E.; Roszkowski, M.; Daszkiewicz, P.; Jóźwiak, S.; Matyja, E. (2011). "Subependymal giant cell astrocytomas with atypical histological features mimicking malignant gliomas.". Folia Neuropathol 49 (1): 39-46. PMID 21455842.
- ↑ 2.0 2.1 URL: http://path.upmc.edu/cases/case179.html. Accessed on: 29 July 2011.
- ↑ 3.0 3.1 Taraszewska, A.; Kroh, H.; Majchrowski, A. (1997). "Subependymal giant cell astrocytoma: clinical, histologic and immunohistochemical characteristic of 3 cases.". Folia Neuropathol 35 (3): 181-6. PMID 9595853.
- ↑ 4.0 4.1 URL: http://path.upmc.edu/cases/case179/micro.html. Accessed on: 8 January 2012.
- ↑ Hirose, T.; Scheithauer, BW.; Lopes, MB.; Gerber, HA.; Altermatt, HJ.; Hukee, MJ.; VandenBerg, SR.; Charlesworth, JC. (1995). "Tuber and subependymal giant cell astrocytoma associated with tuberous sclerosis: an immunohistochemical, ultrastructural, and immunoelectron and microscopic study.". Acta Neuropathol 90 (4): 387-99. PMID 8546029.
- ↑ Hewer, E.; Vajtai, I.. "Consistent nuclear expression of thyroid transcription factor 1 in subependymal giant cell astrocytomas suggests lineage-restricted histogenesis.". Clin Neuropathol 34 (3): 128-31. doi:10.5414/NP300818. PMID 25669749.