Splenic hamartoma

From Libre Pathology
Jump to navigation Jump to search

Splenic hamartoma, also hamartoma of the spleen, is an uncommon benign lesion of the spleen.

Splenic hamartoma
Diagnosis in short

Splenic hamartoma. H&E stain.

LM variable size irregular vascular channels, red pulp-like disorganized stroma, +/-lymphoid follicles
LM DDx littoral cell angioma
IHC factor VIII +ve, CD31 -ve
Gross red, well-circumscribed
Site spleen

Signs +/-splenic enlargement
Symptoms +/-abdominal pain
Prognosis benign
Treatment observe or splenectomy

General

  • Benign.
  • Women > men.[1]
  • May cause pain.[2]

Gross

  • Red lesion.
  • Well-circumscribed.

Image

Microscopic

Features:[3]

  • Variable size irregular vascular channels
  • Red pulp-like disorganized stroma
  • +/-Lymphoid follicles.

DDx:

Images

IHC

Features:

  • CD8 +ve endothelial cells.[3]
  • Factor VIII +ve (diffuse intense).[4]
    • Background spleen -ve.
  • CD31 -ve.[4]
    • Background spleen +ve.

See also

References

  1. Sankar, S.; Thanka, J.; Jagdishchandrabose, S.; Rajendran, S.. "Splenic hamartoma: a rare vascular space occupying lesion of the spleen.". Indian J Pathol Microbiol 54 (1): 223-5. doi:10.4103/0377-4929.77416. PMID 21393931.
  2. Tatekawa, Y.; Kanehiro, H.; Nakajima, Y. (Sep 2007). "Laparoscopic extirpation of splenic hamartoma.". Pediatr Surg Int 23 (9): 911-4. doi:10.1007/s00383-007-1902-1. PMID 17364201.
  3. 3.0 3.1 Lee, H.; Maeda, K. (Jan 2009). "Hamartoma of the spleen.". Arch Pathol Lab Med 133 (1): 147-51. doi:10.1043/1543-2165-133.1.147. PMID 19123729.
  4. 4.0 4.1 Ali, TZ.; Beyer, G.; Taylor, M.; Volpe, C.; Papadimitriou, JC. (Jan 2005). "Splenic hamartoma: immunohistochemical and ultrastructural profile of two cases.". Int J Surg Pathol 13 (1): 103-11. PMID 15735864.