Spermatocytic tumour
Jump to navigation
Jump to search
The printable version is no longer supported and may have rendering errors. Please update your browser bookmarks and please use the default browser print function instead.
Spermatocytic tumour | |
---|---|
Diagnosis in short | |
Spermatocytic tumour | |
| |
Synonyms | spermatocytic seminoma (old term) |
| |
LM | three cell populations: (1) small cells (6-8 µm) - with a large NC ratio, (2) medium cells (15-18 µm) with prominent nucleoli and spireme chromatin, (3) Large cells (50-100 µm) with spireme chromatin; mucoid lakes, intratubular spread |
LM DDx | DLBCL, seminoma |
Site | testis |
| |
Signs | mass lesion |
Prevalence | rare |
Prognosis | benign, good |
Clin. DDx | other germ cell tumours, lymphoma |
Treatment | excision to exclude malignancy |
Spermatocytic tumour is a rare benign testicular tumour.
It was previously known as spermatocytic seminoma. It should not be confused with seminoma which is an unrelated tumour.
General
- Rare tumour.
- Only one case of metastases in 200 cases.[1]
- Orchiectomy is curative.
- Not reported/found in females.[1]
- Typically older - mean age 50s.[1]
Epidemiology
- Does not arise from germ cell neoplasia in situ (previously known as intratubular germ cell neoplasia)[2] - not considered a subtype of seminoma.
Microscopic
Features:[3]
- Population of three cells.
- Mucoid lakes.
- Intratubular spread.
Notes:
- Spireme = the tangle of filaments in prophase portion of mitosis.[4]
- May have eosinophilic cytoplasm (dependent on lab).
- Usually larger than Leydig cell tumour.
DDx:
Images
IHC
Features:[5]
- PLAP -ve (0 positive/17).
- CD117 -ve (7 positive/17).
- CAM5.2 -ve (1 positive/17).
See also
References
- ↑ 1.0 1.1 1.2 1.3 Eble JN (October 1994). "Spermatocytic seminoma". Hum. Pathol. 25 (10): 1035–42. PMID 7927308.
- ↑ Müller J, Skakkebaek NE, Parkinson MC (February 1987). "The spermatocytic seminoma: views on pathogenesis". Int. J. Androl. 10 (1): 147–56. doi:10.1111/j.1365-2605.1987.tb00176.x. PMID 3583416.
- ↑ Cotran, Ramzi S.; Kumar, Vinay; Fausto, Nelson; Nelso Fausto; Robbins, Stanley L.; Abbas, Abul K. (2005). Robbins and Cotran pathologic basis of disease (7th ed.). St. Louis, Mo: Elsevier Saunders. ISBN 0-7216-0187-1.
- ↑ URL: http://www.thefreedictionary.com/spireme. Accessed on: 4 June 2010.
- ↑ Kraggerud, SM.; Berner, A.; Bryne, M.; Pettersen, EO.; Fossa, SD. (Mar 1999). "Spermatocytic seminoma as compared to classical seminoma: an immunohistochemical and DNA flow cytometric study.". APMIS 107 (3): 297-302. PMID 10223302.