Difference between revisions of "Smoking-related interstitial fibrosis"

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*[https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5017577/figure/pone.0162231.g007/ SRIF (nih.gov)].<ref name=pmid27611866/>
*[https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5017577/figure/pone.0162231.g007/ SRIF (nih.gov)].<ref name=pmid27611866/>
*[https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4043428/figure/f1-copd-9-525/ SRIF (nih.gov)].<ref name=pmid24920890>{{Cite journal  | last1 = Primiani | first1 = A. | last2 = Dias-Santagata | first2 = D. | last3 = Iafrate | first3 = AJ. | last4 = Kradin | first4 = RL. | title = Pulmonary adenocarcinoma mutation profile in smokers with smoking-related interstitial fibrosis. | journal = Int J Chron Obstruct Pulmon Dis | volume = 9 | issue =  | pages = 525-31 | month =  | year = 2014 | doi = 10.2147/COPD.S61932 | PMID = 24920890 }}</ref>
*[https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4043428/figure/f1-copd-9-525/ SRIF (nih.gov)].<ref name=pmid24920890>{{Cite journal  | last1 = Primiani | first1 = A. | last2 = Dias-Santagata | first2 = D. | last3 = Iafrate | first3 = AJ. | last4 = Kradin | first4 = RL. | title = Pulmonary adenocarcinoma mutation profile in smokers with smoking-related interstitial fibrosis. | journal = Int J Chron Obstruct Pulmon Dis | volume = 9 | issue =  | pages = 525-31 | month =  | year = 2014 | doi = 10.2147/COPD.S61932 | PMID = 24920890 }}</ref>
*[http://www.nature.com/modpathol/journal/v25/n1s/fig_tab/modpathol2011154f4.html#figure-title SKIF (nature.com)].<ref name=pmid22214972>{{Cite journal  | last1 = Katzenstein | first1 = AL. | title = Smoking-related interstitial fibrosis (SRIF), pathogenesis and treatment of usual interstitial pneumonia (UIP), and transbronchial biopsy in UIP. | journal = Mod Pathol | volume = 25 Suppl 1 | issue =  | pages = S68-78 | month = Jan | year = 2012 | doi = 10.1038/modpathol.2011.154 | PMID = 22214972 }}</ref>
*[http://www.nature.com/modpathol/journal/v25/n1s/fig_tab/modpathol2011154f4.html#figure-title SRIF (nature.com)].<ref name=pmid22214972>{{Cite journal  | last1 = Katzenstein | first1 = AL. | title = Smoking-related interstitial fibrosis (SRIF), pathogenesis and treatment of usual interstitial pneumonia (UIP), and transbronchial biopsy in UIP. | journal = Mod Pathol | volume = 25 Suppl 1 | issue =  | pages = S68-78 | month = Jan | year = 2012 | doi = 10.1038/modpathol.2011.154 | PMID = 22214972 }}</ref>
<!-- *[http://jcp.bmj.com/content/jclinpath/early/2013/04/26/jclinpath-2012-201338.full.pdf SRIF journal paper (bmj.com)]. -->
<!-- *[http://jcp.bmj.com/content/jclinpath/early/2013/04/26/jclinpath-2012-201338.full.pdf SRIF journal paper (bmj.com)]. -->


Revision as of 16:12, 24 March 2017

Smoking-related interstitial fibrosis
Diagnosis in short
LM septal thickening of alveoli with thick collagen bundles (described as "ropy") and hyperplastic smooth muscle fibres; minimal inflammation
LM DDx usual interstitial pneumonia
Gross subpleural and centrilobular predominance
Site lung
Associated Dx emphysema, respiratory bronchiolitis
Clinical history smoking
Prognosis benign, better than UIP

Smoking-related interstitial fibrosis, abbreviated SRIF, is a benign pauci-inflammatory scarring associated with smoking.

General

  • Associated with emphysema and respiratory bronchiolitis.[1]

Clinical:

  • Much better prognosis than UIP with emphysema - five year survival 86% (SRIF) versus 41% (UIP).[2]

Gross

  • Subpleural and centrilobular predominance.[1]

Microscopic

Features:[1]

  • Septal thickening of alveoli with:
    • Thick collagen bundles - may be described as "ropy".[3]
    • Hyperplastic smooth muscle fibres.
  • Minimal inflammation.

DDx:

Images

See also

References

  1. ↑ 1.0 1.1 1.2 1.3 Katzenstein, AL. (Jan 2012). "Smoking-related interstitial fibrosis (SRIF), pathogenesis and treatment of usual interstitial pneumonia (UIP), and transbronchial biopsy in UIP.". Mod Pathol 25 Suppl 1: S68-78. doi:10.1038/modpathol.2011.154. PMID 22214972.
  2. ↑ 2.0 2.1 Chae, KJ.; Jin, GY.; Jung, HN.; Kwon, KS.; Choi, H.; Lee, YC.; Chung, MJ.; Park, HS. (2016). "Differentiating Smoking-Related Interstitial Fibrosis (SRIF) from Usual Interstitial Pneumonia (UIP) with Emphysema Using CT Features Based on Pathologically Proven Cases.". PLoS One 11 (9): e0162231. doi:10.1371/journal.pone.0162231. PMID 27611866.
  3. ↑ 3.0 3.1 Primiani, A.; Dias-Santagata, D.; Iafrate, AJ.; Kradin, RL. (2014). "Pulmonary adenocarcinoma mutation profile in smokers with smoking-related interstitial fibrosis.". Int J Chron Obstruct Pulmon Dis 9: 525-31. doi:10.2147/COPD.S61932. PMID 24920890.
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