Difference between revisions of "Smoking-related interstitial fibrosis"

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'''Smoking-related interstitial fibrosis''', abbreviated '''SRIF''', is a benign pauci-inflammatory fibrosis associated with [[smoking]].  
{{ Infobox diagnosis
| Name      = {{PAGENAME}}
| Image      =
| Width      =
| Caption    =
| Synonyms  =
| Micro      = septal thickening of alveoli with thick collagen bundles (described as "ropy") and hyperplastic smooth muscle fibres; minimal inflammation
| Subtypes  =
| LMDDx      = [[usual interstitial pneumonia]]
| Stains    =
| IHC        =
| EM        =
| Molecular  =
| IF        =
| Gross      = subpleural and centrilobular predominance
| Grossing  =
| Staging    =
| Site      = [[lung]]
| Assdx      = [[emphysema]], respiratory bronchiolitis
| Syndromes  =
| Clinicalhx = [[smoking]]
| Signs      =
| Symptoms  =
| Prevalence =
| Bloodwork  =
| Rads      =
| Endoscopy  =
| Prognosis  = benign, better than UIP
| Other      =
| ClinDDx    =
| Tx        =
}}
'''Smoking-related interstitial fibrosis''', abbreviated '''SRIF''', is a benign pauci-inflammatory scarring associated with [[smoking]].  


==General==
==General==
*Associated with emphysema and respiratory bronchiolitis.<ref name=pmid22214972/>
*Associated with emphysema and respiratory bronchiolitis.<ref name=pmid22214972/>
Clinical:
*Much better prognosis than [[usual interstitial pneumonia]] (UIP) with [[emphysema]] - five year survival 86% (SRIF) versus 41% (UIP).<ref name=pmid27611866>{{Cite journal  | last1 = Chae | first1 = KJ. | last2 = Jin | first2 = GY. | last3 = Jung | first3 = HN. | last4 = Kwon | first4 = KS. | last5 = Choi | first5 = H. | last6 = Lee | first6 = YC. | last7 = Chung | first7 = MJ. | last8 = Park | first8 = HS. | title = Differentiating Smoking-Related Interstitial Fibrosis (SRIF) from Usual Interstitial Pneumonia (UIP) with Emphysema Using CT Features Based on Pathologically Proven Cases. | journal = PLoS One | volume = 11 | issue = 9 | pages = e0162231 | month =  | year = 2016 | doi = 10.1371/journal.pone.0162231 | PMID = 27611866 }}</ref>


==Gross==
==Gross==
Line 16: Line 51:
DDx:
DDx:
*[[Usual interstitial pneumonia]] - has inflammation.
*[[Usual interstitial pneumonia]] - has inflammation.
===Images===
*[https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5017577/figure/pone.0162231.g007/ SRIF (nih.gov)].<ref name=pmid27611866/>
*[https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4043428/figure/f1-copd-9-525/ SRIF (nih.gov)].<ref name=pmid24920890>{{Cite journal  | last1 = Primiani | first1 = A. | last2 = Dias-Santagata | first2 = D. | last3 = Iafrate | first3 = AJ. | last4 = Kradin | first4 = RL. | title = Pulmonary adenocarcinoma mutation profile in smokers with smoking-related interstitial fibrosis. | journal = Int J Chron Obstruct Pulmon Dis | volume = 9 | issue =  | pages = 525-31 | month =  | year = 2014 | doi = 10.2147/COPD.S61932 | PMID = 24920890 }}</ref>
*[http://www.nature.com/modpathol/journal/v25/n1s/fig_tab/modpathol2011154f4.html#figure-title SRIF (nature.com)].<ref name=pmid22214972>{{Cite journal  | last1 = Katzenstein | first1 = AL. | title = Smoking-related interstitial fibrosis (SRIF), pathogenesis and treatment of usual interstitial pneumonia (UIP), and transbronchial biopsy in UIP. | journal = Mod Pathol | volume = 25 Suppl 1 | issue =  | pages = S68-78 | month = Jan | year = 2012 | doi = 10.1038/modpathol.2011.154 | PMID = 22214972 }}</ref>
<!-- *[http://jcp.bmj.com/content/jclinpath/early/2013/04/26/jclinpath-2012-201338.full.pdf SRIF journal paper (bmj.com)]. -->


==See also==
==See also==
*[[Smoking]].
*[[Smoking]].
*[[Desquamative interstitial pneumonia]].


==References==
==References==

Latest revision as of 17:16, 8 May 2019

Smoking-related interstitial fibrosis
Diagnosis in short

LM septal thickening of alveoli with thick collagen bundles (described as "ropy") and hyperplastic smooth muscle fibres; minimal inflammation
LM DDx usual interstitial pneumonia
Gross subpleural and centrilobular predominance
Site lung

Associated Dx emphysema, respiratory bronchiolitis
Clinical history smoking
Prognosis benign, better than UIP

Smoking-related interstitial fibrosis, abbreviated SRIF, is a benign pauci-inflammatory scarring associated with smoking.

General

  • Associated with emphysema and respiratory bronchiolitis.[1]

Clinical:

Gross

  • Subpleural and centrilobular predominance.[1]

Microscopic

Features:[1]

  • Septal thickening of alveoli with:
    • Thick collagen bundles - may be described as "ropy".[3]
    • Hyperplastic smooth muscle fibres.
  • Minimal inflammation.

DDx:

Images

See also

References

  1. 1.0 1.1 1.2 1.3 Katzenstein, AL. (Jan 2012). "Smoking-related interstitial fibrosis (SRIF), pathogenesis and treatment of usual interstitial pneumonia (UIP), and transbronchial biopsy in UIP.". Mod Pathol 25 Suppl 1: S68-78. doi:10.1038/modpathol.2011.154. PMID 22214972.
  2. 2.0 2.1 Chae, KJ.; Jin, GY.; Jung, HN.; Kwon, KS.; Choi, H.; Lee, YC.; Chung, MJ.; Park, HS. (2016). "Differentiating Smoking-Related Interstitial Fibrosis (SRIF) from Usual Interstitial Pneumonia (UIP) with Emphysema Using CT Features Based on Pathologically Proven Cases.". PLoS One 11 (9): e0162231. doi:10.1371/journal.pone.0162231. PMID 27611866.
  3. 3.0 3.1 Primiani, A.; Dias-Santagata, D.; Iafrate, AJ.; Kradin, RL. (2014). "Pulmonary adenocarcinoma mutation profile in smokers with smoking-related interstitial fibrosis.". Int J Chron Obstruct Pulmon Dis 9: 525-31. doi:10.2147/COPD.S61932. PMID 24920890.