Small round cell tumours

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Revision as of 19:23, 16 February 2011 by Michael (talk | contribs) (+table)
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Small round cell tumours (SRCT), also small round blue cell tumours (SRBCT), are a group of tumours that have a similar histologic appearance.

It is a group of tumours that is seen more often in childhood than adulthood.

DDx:[1]

Memory device: 4 -blastoma (hepato-, neuro-, nephro-, retino-), PNET/Ewing sarcoma (medulloblastoma), DSRCT, lymphoma, alveolar rhabdomyosarcoma.

Microscopic

Features:

  • Sheets of cells, very cellular.
  • Small cells ~ 2X RBC diameter.
  • Scant cytoplasm.
  • Coarse chromatin.
  • +/-Nucleolus. (???)
  • +/-Vascular.

Tabular comparison

Tumour Key histologic features History Key IHC
Hepatoblastoma liver AFP (?)
Neuroblastoma adrenal gland, sympathetic chain NB-84
Nephroblastoma (Wilms tumour) triphasic - (1) blue cells (blastema), (2) spindle cells (stroma), (3) tubular structures (epithelial) kidney WT-1
Retinoblastoma eye
Medulloblastoma
Ewing sarcoma/PNET
Rhabdomyosarcoma "DAM" = desmin, actin, myogenin
Desmoplastic small round cell tumour (DSRCT)
Small cell carcinoma stippled chromatin, nuclear moulding synaptophysin, chromogranin, CD56, keratins
Lymphoma dyscohesive CD45

See also

References