Difference between revisions of "Small round cell tumours"
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| Lymphoma (large cell) | | Lymphoma (large cell) | ||
| dyscohesive, ~2x normal (resting) lymphocyte | | dyscohesive cells, ~2x normal (resting) lymphocyte, nucleolus | ||
| lymphadenopathy (???) | | lymphadenopathy (???) | ||
| CD45 | | CD45 | ||
Revision as of 16:17, 28 February 2011
Small round cell tumours (SRCT), also small round blue cell tumours (SRBCT), are a group of tumours that have a similar histologic appearance.
It is a group of tumours that is seen more often in childhood than adulthood.
DDx:[1]
- Neuroblastoma.
- Wilms tumour (AKA nephroblastoma).
- Alveolar rhabdomyosarcoma.
- Ewing sarcoma/PNET - this entity is dealt with in the bone tumours article.
- Lymphoma - large cell lymphomas, e.g. diffuse large B cell lymphoma, anaplastic large cell lymphoma.
- Retinoblastoma.
- Hepatoblastoma.
- Desmoplastic small round cell tumour (DSRCT).
Memory device: 4 -blastoma (hepato-, neuro-, nephro-, retino-), PNET/Ewing sarcoma (medulloblastoma), DSRCT, lymphoma, alveolar rhabdomyosarcoma.
Microscopic
Features:
- Sheets of cells, very cellular.
- Small cells ~ 2X RBC diameter.
- Scant cytoplasm.
- Coarse chromatin.
- +/-Nucleolus. (???)
- +/-Vascular.
Tabular comparison
| Tumour | Key histologic features | History | Key IHC / special stains |
| Hepatoblastoma | liver | AFP | |
| Neuroblastoma | nests, thin fibrovascular septae, lymphocytes, ganglion-like cells (prominent nucleolus), neurophil (eosinophilic, fluffy, finely vacuolated) | adrenal gland, sympathetic chain; usu. < 3 years old | NB-84+, NSE+, S100- |
| Nephroblastoma (Wilms tumour) | triphasic - (1) blue cells (blastema), (2) spindle cells (stroma), (3) tubular structures (epithelial) | kidney | WT-1+ |
| Retinoblastoma | eye | ||
| Medulloblastoma | |||
| Ewing sarcoma/PNET | clear cytoplasm (glycogen) | bone lesion, adolescents | PAS+/PASD-, CD99 diffuse membranous |
| Rhabdomyosarcoma, alveolar | rhabdomyocytes (eosinophilic cytoplasm +/-cross striations (uncommon), eccentric nucleus) | adolescents, young adults; often mets at presentation | "DAM" = desmin, actin, myogenin |
| Rhabdomyosarcoma, embryonal | rhabdomyocytes (elongated/cigar-shaped cells, eosinophilic cytoplasm +/-cross striations, eccentric nucleus), nests with rounded border | <10 years old; usu. localized | "DAM" = desmin, actin, myogenin |
| Desmoplastic small round cell tumour (DSRCT) | nests with "jigsaw" border | peritoneum (abdomen or plevis); male > female; locally invasive | keratin+, EMA+, desmin+ !!! |
| Small cell carcinoma | stippled chromatin, nuclear moulding | adults, smokers | synaptophysin, chromogranin, CD56, keratins |
| Lymphoma (large cell) | dyscohesive cells, ~2x normal (resting) lymphocyte, nucleolus | lymphadenopathy (???) | CD45 |
See also
References
- ↑ URL: http://www.thedoctorsdoctor.com/diseases/small_round_blue_cell_tumor.htm. Accessed on: 2 July 2010.