Difference between revisions of "Small round cell tumours"

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(fix sp., wikify)
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*+/-Vascular.
*+/-Vascular.


==Tabular comparison==
{| class="wikitable"
| '''Tumour'''
| '''Key histologic features'''
| '''History'''
| '''Key [[IHC]]'''
|-
| Hepatoblastoma
|
| liver
| AFP (?)
|-
| Neuroblastoma
|
| adrenal gland, sympathetic chain
| NB-84
|-
| Nephroblastoma (Wilms tumour)
| triphasic - (1) blue cells (blastema), (2) spindle cells (stroma), (3) tubular structures (epithelial)
| kidney
| WT-1
|-
| Retinoblastoma
|
| eye
|
|-
| Medulloblastoma
|
|
|
|-
| Ewing sarcoma/PNET
|
|
|
|-
| Rhabdomyosarcoma
|
|
| "DAM" = desmin, actin, myogenin
|-
| Desmoplastic small round cell tumour (DSRCT)
|
|
|
|-
| Small cell carcinoma
| stippled chromatin, nuclear moulding
|
| synaptophysin, chromogranin, CD56, keratins
|-
| Lymphoma
| dyscohesive
|
| CD45
|-
|}
==See also==
==See also==
*[[Soft tissue lesions]].
*[[Soft tissue lesions]].

Revision as of 19:23, 16 February 2011

Small round cell tumours (SRCT), also small round blue cell tumours (SRBCT), are a group of tumours that have a similar histologic appearance.

It is a group of tumours that is seen more often in childhood than adulthood.

DDx:[1]

Memory device: 4 -blastoma (hepato-, neuro-, nephro-, retino-), PNET/Ewing sarcoma (medulloblastoma), DSRCT, lymphoma, alveolar rhabdomyosarcoma.

Microscopic

Features:

  • Sheets of cells, very cellular.
  • Small cells ~ 2X RBC diameter.
  • Scant cytoplasm.
  • Coarse chromatin.
  • +/-Nucleolus. (???)
  • +/-Vascular.

Tabular comparison

Tumour Key histologic features History Key IHC
Hepatoblastoma liver AFP (?)
Neuroblastoma adrenal gland, sympathetic chain NB-84
Nephroblastoma (Wilms tumour) triphasic - (1) blue cells (blastema), (2) spindle cells (stroma), (3) tubular structures (epithelial) kidney WT-1
Retinoblastoma eye
Medulloblastoma
Ewing sarcoma/PNET
Rhabdomyosarcoma "DAM" = desmin, actin, myogenin
Desmoplastic small round cell tumour (DSRCT)
Small cell carcinoma stippled chromatin, nuclear moulding synaptophysin, chromogranin, CD56, keratins
Lymphoma dyscohesive CD45

See also

References