Small cell carcinoma of the urinary bladder
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Small cell carcinoma of the urinary bladder, abbreviated SCCUB, is a rare malignant neoplasm of the urinary bladder.
| Small cell carcinoma of the urinary bladder | |
|---|---|
| Diagnosis in short | |
 Small cell carcinoma of the urinary bladder. H&E stain. | |
| LM DDx | small cell carcinoma of the prostate gland, lymphoma (large cell), other small round blue cell tumours |
| Stains | pankeratin +ve, chromogranin +ve, synaptophysin +ve, CD56 +ve |
| Site | urinary bladder |
|
| |
| Symptoms | +/-hematuria |
| Prevalence | very rare |
| Prognosis | poor |
| Clin. DDx | other bladder tumours esp. urothelial carcinoma |
General
- Very rare[1] - less than 1% of bladder cancers in one series.[2]
- Poor prognosis[1] - survival ~ 11 months.[2]
Clinical:
- Hematuria - typical presentation.[2]
Epidemiology:
Microscopic
Features:
- See small cell carcinoma.
Note:
- Usually co-exists with urothelial carcinoma ~60% of cases in one series.[2]
DDx:
- Small cell carcinoma of the prostate gland.
- Lymphoma, large cell.
- Other small round blue cell tumours.
Images
SmCC bladder - intermed. mag.
SmCC bladder - high mag.
SmCC bladder - very high mag.
IHC
- Pankeratin +ve,
- Chromogranin +ve.
- Synaptophysin +ve.
- CD56 +ve.
See also
References
- ↑ 1.0 1.1 Koga, F.; Yokoyama, M.; Fukushima, H. (Nov 2013). "Small cell carcinoma of the urinary bladder: a contemporary review with a special focus on bladder-sparing treatments.". Expert Rev Anticancer Ther 13 (11): 1269-79. doi:10.1586/14737140.2013.851605. PMID 24168010.
- ↑ 2.0 2.1 2.2 2.3 2.4 Hou, CP.; Lin, YH.; Chen, CL.; Chang, PL.; Tsui, KH. (2013). "Clinical outcome of primary small cell carcinoma of the urinary bladder.". Onco Targets Ther 6: 1179-85. doi:10.2147/OTT.S49879. PMID 24009428.