Difference between revisions of "Small cell carcinoma of the urinary bladder"
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{{ Infobox diagnosis | {{ Infobox diagnosis | ||
| Name = {{PAGENAME}} | | Name = {{PAGENAME}} | ||
| Image = | | Image = Small cell carcinoma of the urinary bladder -- very high mag.jpg | ||
| Width = | | Width = | ||
| Caption = | | Caption = [[Small cell carcinoma]] of the urinary bladder. [[H&E stain]]. | ||
| Synonyms = | | Synonyms = | ||
| Micro = | | Micro = | ||
| Subtypes = | | Subtypes = | ||
| LMDDx = [[small cell carcinoma of the prostate gland]], [[lymphoma]] (large cell), other [[small round blue cell tumours]] | | LMDDx = [[small cell carcinoma of the prostate gland]], [[lymphoma]] (large cell), other [[small round blue cell tumours]] | ||
| Stains = pankeratin +ve, chromogranin +ve, synaptophysin +ve, CD56 +ve | | Stains = [[pankeratin]] +ve, chromogranin +ve, synaptophysin +ve, [[CD56]] +ve | ||
| IHC = | | IHC = | ||
| EM = | | EM = | ||
| Line 30: | Line 30: | ||
| Tx = | | Tx = | ||
}} | }} | ||
'''Small cell carcinoma of the urinary bladder''' is a rare malignant neoplasm of the [[urinary bladder]]. | '''Small cell carcinoma of the urinary bladder''', abbreviated '''SCCUB''', is a rare malignant neoplasm of the [[urinary bladder]]. | ||
==General== | ==General== | ||
*Very rare | *Very rare<ref name=pmid24168010>{{Cite journal | last1 = Koga | first1 = F. | last2 = Yokoyama | first2 = M. | last3 = Fukushima | first3 = H. | title = Small cell carcinoma of the urinary bladder: a contemporary review with a special focus on bladder-sparing treatments. | journal = Expert Rev Anticancer Ther | volume = 13 | issue = 11 | pages = 1269-79 | month = Nov | year = 2013 | doi = 10.1586/14737140.2013.851605 | PMID = 24168010 }}</ref> - less than 1% of bladder cancers in one series.<ref name=pmid24009428>{{Cite journal | last1 = Hou | first1 = CP. | last2 = Lin | first2 = YH. | last3 = Chen | first3 = CL. | last4 = Chang | first4 = PL. | last5 = Tsui | first5 = KH. | title = Clinical outcome of primary small cell carcinoma of the urinary bladder. | journal = Onco Targets Ther | volume = 6 | issue = | pages = 1179-85 | month = | year = 2013 | doi = 10.2147/OTT.S49879 | PMID = 24009428 }}</ref> | ||
*Poor prognosis.<ref name= | *Poor prognosis<ref name=pmid24168010/> - survival ~ 11 months.<ref name=pmid24009428/> | ||
Clinical: | |||
*Hematuria - typical presentation.<ref name=pmid24009428/> | |||
Epidemiology: | |||
*[[Smoking]] - very common.<ref name=pmid24009428/> | |||
==Microscopic== | ==Microscopic== | ||
Features: | Features: | ||
*See ''[[small cell carcinoma]]''. | *See ''[[small cell carcinoma]]''. | ||
Note: | |||
*Usually co-exists with [[urothelial carcinoma]] ~60% of cases in one series.<ref name=pmid24009428/> | |||
DDx: | DDx: | ||
| Line 44: | Line 53: | ||
*[[Lymphoma]], large cell. | *[[Lymphoma]], large cell. | ||
*Other [[small round blue cell tumours]]. | *Other [[small round blue cell tumours]]. | ||
===Images=== | ===Images=== | ||
| Line 57: | Line 60: | ||
Image: Small cell carcinoma of the urinary bladder -- very high mag.jpg | SmCC bladder - very high mag. | Image: Small cell carcinoma of the urinary bladder -- very high mag.jpg | SmCC bladder - very high mag. | ||
</gallery> | </gallery> | ||
==IHC== | |||
*[[Pankerati]]n +ve, | |||
*Chromogranin +ve. | |||
*Synaptophysin +ve. | |||
*[[CD56]] +ve. | |||
==See also== | ==See also== | ||
Revision as of 21:31, 1 August 2016
| Small cell carcinoma of the urinary bladder | |
|---|---|
| Diagnosis in short | |
 Small cell carcinoma of the urinary bladder. H&E stain. | |
| LM DDx | small cell carcinoma of the prostate gland, lymphoma (large cell), other small round blue cell tumours |
| Stains | pankeratin +ve, chromogranin +ve, synaptophysin +ve, CD56 +ve |
| Site | urinary bladder |
|
| |
| Symptoms | +/-hematuria |
| Prevalence | very rare |
| Prognosis | poor |
| Clin. DDx | other bladder tumours esp. urothelial carcinoma |
Small cell carcinoma of the urinary bladder, abbreviated SCCUB, is a rare malignant neoplasm of the urinary bladder.
General
- Very rare[1] - less than 1% of bladder cancers in one series.[2]
- Poor prognosis[1] - survival ~ 11 months.[2]
Clinical:
- Hematuria - typical presentation.[2]
Epidemiology:
Microscopic
Features:
- See small cell carcinoma.
Note:
- Usually co-exists with urothelial carcinoma ~60% of cases in one series.[2]
DDx:
- Small cell carcinoma of the prostate gland.
- Lymphoma, large cell.
- Other small round blue cell tumours.
Images
SmCC bladder - intermed. mag.
SmCC bladder - high mag.
SmCC bladder - very high mag.
IHC
- Pankeratin +ve,
- Chromogranin +ve.
- Synaptophysin +ve.
- CD56 +ve.
See also
References
- ↑ 1.0 1.1 Koga, F.; Yokoyama, M.; Fukushima, H. (Nov 2013). "Small cell carcinoma of the urinary bladder: a contemporary review with a special focus on bladder-sparing treatments.". Expert Rev Anticancer Ther 13 (11): 1269-79. doi:10.1586/14737140.2013.851605. PMID 24168010.
- ↑ 2.0 2.1 2.2 2.3 2.4 Hou, CP.; Lin, YH.; Chen, CL.; Chang, PL.; Tsui, KH. (2013). "Clinical outcome of primary small cell carcinoma of the urinary bladder.". Onco Targets Ther 6: 1179-85. doi:10.2147/OTT.S49879. PMID 24009428.