Small cell carcinoma of the prostate gland

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Small cell carcinoma of the prostate gland
Diagnosis in short

Small cell carcinoma of the prostate. H&E stain.

LM small cells with nuclear moulding, stippled chromatin and high NC ratio, +/-high-grade acinar adenocarcinoma (common)
LM DDx small cell carcinoma of the urinary bladder, metastatic small cell carcinoma, poorly differentiated prostate carcinoma
IHC chromogranin A +ve, PSA -ve/+ve
Grossing notes prostate biopsy, prostate chips, radical prostatectomy
Site prostate gland - see prostate cancer

Prevalence rare
Prognosis poor
Clin. DDx other types of prostate cancer, metastatic cancer
Treatment chemotherapy

Small cell carcinoma of the prostate gland is a rare type of prostate cancer with an aggressive course.

Neuroendocrine carcinoma of the prostate redirects to here.[1][2]

General

Clinical:

  • PSA often low in comparison to conventional prostate cancer.[3]

Microscopic

Features:

  • Small cells with:
    • Nuclear moulding.
    • Stippled chromatin.
    • High NC ratio.
  • +/-High-grade acinar adenocarcinoma, i.e. conventional prostate carcinoma, seen in ~50% of cases.[3]

Notes:

DDx:

Images

Case

www

IHC

Features:[3]

  • PSA weak +ve/-ve.
  • Chromogranin +ve.

See also

References

  1. Stein, ME.; Bernstein, Z.; Abacioglu, U.; Sengoz, M.; Miller, RC.; Meirovitz, A.; Zouhair, A.; Freixa, SV. et al. (Dec 2008). "Small cell (neuroendocrine) carcinoma of the prostate: etiology, diagnosis, prognosis, and therapeutic implications--a retrospective study of 30 patients from the rare cancer network.". Am J Med Sci 336 (6): 478-88. doi:10.1097/MAJ.0b013e3181731e58. PMID 19092321.
  2. Alanee, S.; Moore, A.; Nutt, M.; Holland, B.; Dynda, D.; El-Zawahry, A.; McVary, KT. (Jul 2015). "Contemporary Incidence and Mortality Rates of Neuroendocrine Prostate Cancer.". Anticancer Res 35 (7): 4145-50. PMID 26124369.
  3. 3.0 3.1 3.2 3.3 3.4 Furtado, P.; Lima, MV.; Nogueira, C.; Franco, M.; Tavora, F. (2011). "Review of small cell carcinomas of the prostate.". Prostate Cancer 2011: 543272. doi:10.1155/2011/543272. PMID 22110988.
  4. Epstein, JI.; Allsbrook, WC.; Amin, MB.; Egevad, LL. (Sep 2005). "The 2005 International Society of Urological Pathology (ISUP) Consensus Conference on Gleason Grading of Prostatic Carcinoma.". Am J Surg Pathol 29 (9): 1228-42. PMID 16096414.