Small cell carcinoma of the prostate gland

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Small cell carcinoma of the prostate gland is a rare type of prostate cancer with an aggressive course.

General

Microscopic

Features:

  • Small cells with:
    • Nuclear moulding.
    • Stippled chromatin.
    • High NC ratio.
  • +/-High-grade acinar adenocarcinoma, i.e. conventional prostate carcinoma, seen in ~50% of cases.[1]

Notes:

DDx:

Images

www

IHC

Features:[1]

  • PSA weak +ve/-ve.
  • Chromogranin +ve.

See also

References

  1. 1.0 1.1 1.2 1.3 Furtado, P.; Lima, MV.; Nogueira, C.; Franco, M.; Tavora, F. (2011). "Review of small cell carcinomas of the prostate.". Prostate Cancer 2011: 543272. doi:10.1155/2011/543272. PMID 22110988.
  2. Epstein, JI.; Allsbrook, WC.; Amin, MB.; Egevad, LL. (Sep 2005). "The 2005 International Society of Urological Pathology (ISUP) Consensus Conference on Gleason Grading of Prostatic Carcinoma.". Am J Surg Pathol 29 (9): 1228-42. PMID 16096414.