Difference between revisions of "Small cell carcinoma of the prostate gland"

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| Gross      =
| Gross      =
| Grossing  = [[prostate biopsy]], [[prostate chips]], [[radical prostatectomy]]
| Grossing  = [[prostate biopsy]], [[prostate chips]], [[radical prostatectomy]]
| Staging    =  
| Staging    = [[prostate cancer staging]]
| Site      = [[prostate gland]] - see ''[[prostate cancer]]''
| Site      = [[prostate gland]] - see ''[[prostate cancer]]''
| Assdx      =
| Assdx      =

Revision as of 03:41, 9 February 2016

Small cell carcinoma of the prostate gland
Diagnosis in short

Small cell carcinoma of the prostate. H&E stain.

LM small cells with nuclear moulding, stippled chromatin and high NC ratio, +/-high-grade acinar adenocarcinoma (common)
LM DDx small cell carcinoma of the urinary bladder, metastatic small cell carcinoma, poorly differentiated prostate carcinoma
IHC chromogranin A +ve, PSA -ve/+ve
Grossing notes prostate biopsy, prostate chips, radical prostatectomy
Staging prostate cancer staging
Site prostate gland - see prostate cancer

Prevalence rare
Blood work PSA low (in relation to conventional cancer)
Prognosis poor
Clin. DDx other types of prostate cancer, metastatic cancer
Treatment chemotherapy

Small cell carcinoma of the prostate gland is a rare type of prostate cancer with an aggressive course.

Neuroendocrine carcinoma of the prostate redirects to here.[1][2]

General

Clinical:

  • PSA often low in comparison to conventional prostate cancer.[3]

Microscopic

Features:

  • Small cells with:
    • Nuclear moulding.
    • Stippled chromatin.
    • High NC ratio.
  • +/-High-grade acinar adenocarcinoma, i.e. conventional prostate carcinoma, seen in ~50% of cases.[3]

Notes:

DDx:

Images

Case

www

IHC

Features:[3]

  • PSA weak +ve/-ve.
  • Chromogranin +ve.

See also

References

  1. Stein, ME.; Bernstein, Z.; Abacioglu, U.; Sengoz, M.; Miller, RC.; Meirovitz, A.; Zouhair, A.; Freixa, SV. et al. (Dec 2008). "Small cell (neuroendocrine) carcinoma of the prostate: etiology, diagnosis, prognosis, and therapeutic implications--a retrospective study of 30 patients from the rare cancer network.". Am J Med Sci 336 (6): 478-88. doi:10.1097/MAJ.0b013e3181731e58. PMID 19092321.
  2. Alanee, S.; Moore, A.; Nutt, M.; Holland, B.; Dynda, D.; El-Zawahry, A.; McVary, KT. (Jul 2015). "Contemporary Incidence and Mortality Rates of Neuroendocrine Prostate Cancer.". Anticancer Res 35 (7): 4145-50. PMID 26124369.
  3. 3.0 3.1 3.2 3.3 3.4 Furtado, P.; Lima, MV.; Nogueira, C.; Franco, M.; Tavora, F. (2011). "Review of small cell carcinomas of the prostate.". Prostate Cancer 2011: 543272. doi:10.1155/2011/543272. PMID 22110988.
  4. Epstein, JI.; Allsbrook, WC.; Amin, MB.; Egevad, LL. (Sep 2005). "The 2005 International Society of Urological Pathology (ISUP) Consensus Conference on Gleason Grading of Prostatic Carcinoma.". Am J Surg Pathol 29 (9): 1228-42. PMID 16096414.