Difference between revisions of "Small cell carcinoma of the prostate gland"

From Libre Pathology
Jump to navigation Jump to search
(+infobox)
Line 1: Line 1:
{{ Infobox diagnosis
| Name      = {{PAGENAME}}
| Image      =
| Width      =
| Caption    =
| Synonyms  =
| Micro      = small cells with nuclear moulding, stippled chromatin and high [[NC ratio]], +/-high-grade acinar adenocarcinoma (common)
| Subtypes  =
| LMDDx      = [[small cell carcinoma of the urinary bladder]], metastatic [[small cell carcinoma]], poorly differentiated [[prostate carcinoma]]
| Stains    =
| IHC        = chromogranin A +ve, PSA -ve/+ve
| EM        =
| Molecular  =
| IF        =
| Gross      =
| Grossing  = [[prostate biopsy]], [[prostate chips]], [[radical prostatectomy]]
| Staging    =
| Site      = [[prostate gland]] - see ''[[prostate cancer]]''
| Assdx      =
| Syndromes  =
| Clinicalhx =
| Signs      =
| Symptoms  =
| Prevalence = rare
| Bloodwork  =
| Rads      =
| Endoscopy  =
| Prognosis  = poor
| Other      =
| ClinDDx    = other types of [[prostate cancer]], metastatic cancer
| Tx        = chemotherapy
}}
'''Small cell carcinoma of the prostate gland''' is a rare type of [[prostate cancer]] with an aggressive course.
'''Small cell carcinoma of the prostate gland''' is a rare type of [[prostate cancer]] with an aggressive course.



Revision as of 04:41, 24 January 2016

Small cell carcinoma of the prostate gland
Diagnosis in short

LM small cells with nuclear moulding, stippled chromatin and high NC ratio, +/-high-grade acinar adenocarcinoma (common)
LM DDx small cell carcinoma of the urinary bladder, metastatic small cell carcinoma, poorly differentiated prostate carcinoma
IHC chromogranin A +ve, PSA -ve/+ve
Grossing notes prostate biopsy, prostate chips, radical prostatectomy
Site prostate gland - see prostate cancer

Prevalence rare
Prognosis poor
Clin. DDx other types of prostate cancer, metastatic cancer
Treatment chemotherapy

Small cell carcinoma of the prostate gland is a rare type of prostate cancer with an aggressive course.

General

Microscopic

Features:

  • Small cells with:
    • Nuclear moulding.
    • Stippled chromatin.
    • High NC ratio.
  • +/-High-grade acinar adenocarcinoma, i.e. conventional prostate carcinoma, seen in ~50% of cases.[1]

Notes:

DDx:

Images

www

IHC

Features:[1]

  • PSA weak +ve/-ve.
  • Chromogranin +ve.

See also

References

  1. 1.0 1.1 1.2 1.3 Furtado, P.; Lima, MV.; Nogueira, C.; Franco, M.; Tavora, F. (2011). "Review of small cell carcinomas of the prostate.". Prostate Cancer 2011: 543272. doi:10.1155/2011/543272. PMID 22110988.
  2. Epstein, JI.; Allsbrook, WC.; Amin, MB.; Egevad, LL. (Sep 2005). "The 2005 International Society of Urological Pathology (ISUP) Consensus Conference on Gleason Grading of Prostatic Carcinoma.". Am J Surg Pathol 29 (9): 1228-42. PMID 16096414.