Small cell carcinoma

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Small cell carcinoma is a type of carcinoma. It is mostly commonly from the lung ~95% of cases.[1]

Overview

Grouping

May be grouped as:[1]

Sites other than lung

General

Classic tumour with paraneoplastic syndromes - may be associated with:[4]

  • Syndrome of inappropriate antidiuretic hormone secretion (SIADH).
    • Clinical: hyponatremia.
  • Paraneoplastic cerebellar degeneration.
  • Lambert-Eaton myasthenic syndrome.

Microscopic

Features:

  • Small cells -- typically 15-20 micrometers ~ 2x the size of RBC.
  • Scant cytoplasm.
  • Stippled chromatin.
  • +/-Nuclear moulding.

Images:

DDx:

Special types

Ovarian small cell carcinoma of the hypercalcemic type

  • AKA small cell carcinoma, hypercalcemic type.

General

  • Hypercalcemia.[5]
  • Rare.

Microscopic

Features:[5]

  • Small cell carcinoma.
  • Follicle-like spaces.

See also

References

  1. 1.0 1.1 Grossman, RA.; Pedroso, FE.; Byrne, MM.; Koniaris, LG.; Misra, S. (May 2011). "Does surgery or radiation therapy impact survival for patients with extrapulmonary small cell cancers?". J Surg Oncol. doi:10.1002/jso.21976. PMID 21618245.
  2. Cesaretti, M.; Guarnieri, A.; Gaggelli, I.; Tirone, A.; Francioli, N.; Carli, AF.. "Small cell carcinoma of the breast. Report of a case.". Ann Ital Chir 82 (1): 61-4. PMID 21657157.
  3. Beach, DF.; Klump, WJ.; Haddad, G.; Reid, LM.; Schwarting, R.; Hageboutros, A. (Jun 2011). "Extrapulmonary small cell: a novel case of small cell carcinoma of the thyroid gland.". Med Oncol. doi:10.1007/s12032-011-9996-7. PMID 21644012.
  4. Sher, T.; Dy, GK.; Adjei, AA. (Mar 2008). "Small cell lung cancer.". Mayo Clin Proc 83 (3): 355-67. PMID 18316005.
  5. 5.0 5.1 Young, RH.; Oliva, E.; Scully, RE. (Nov 1994). "Small cell carcinoma of the ovary, hypercalcemic type. A clinicopathological analysis of 150 cases.". Am J Surg Pathol 18 (11): 1102-16. PMID 7943531.